RNA regulation and disease
Moving in bioRxiv, Cancer Research, Cell Reports, Science, Blood, Cell, Cellular & molecular immunology, Journal of Experimental Medicine.
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Latest in RNA regulation and disease
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Nuclear stress-induced modification of NCBP1 at cysteine 436 causes alternative splicing of over 250 genes, including S6 kinase, leading to translation inhibition.
- Open access
- 1 cites
Plakophilin 1 (PKP1) suppresses keratinocyte innate immune responses by sequestering RNA helicases, preventing excessive inflammation in healthy skin cells.
- Open access
Viral delivery of PRPF31 restores splicing, cellular function, and visual activity in patient-derived retinal cells, even in mature stages, offering a promising therapy for RP11.
- Open access
DIS3's 3'-5' exoribonucleolytic activity is essential for resolving backtracked transcription complexes in Homo sapiens, facilitating efficient RNA polymerase II elongation.
- Open access
Viral Interference Programmable Repeat (VIPR) systems reveal a noncontiguous RNA code for DNA recognition, shedding light on the origin of CRISPR-Cas immunity.
- 1 cites
Natural RNA phosphorothioates and their enzymatic machinery are identified across diverse archaeal species, marking the first discovery of phosphate-backbone modifications in RNA.
VIPR systems achieve precise DNA targeting through noncontiguous triplex formation, with 21 cryo-EM structures revealing the mechanism of target engagement.
- 2 cites
SMARCB1-deficient tumors are highly sensitive to H3K27 demethylase inhibitors, with GSK-J4 suppressing tumor growth in patient-derived models.
AAV9 delivery enables mitochondrial adenine base editing in mouse tissues, achieving modest A-to-G conversions over six months.
- Open access
Loss-of-function variants in ADAR1 cause a new interferon-dependent psoriasis subtype with early onset and strong immune signatures.
GLUL promotes thrombocytopoiesis by preventing ammonia buildup during megakaryocyte polyploidization, with deficiency impairing platelet production in mice.
- Open access
Cas12a chRDNA genome editing achieves near-complete target gene disruption with high specificity and no detectable off-target effects in vivo.
- Open access
PARK7-mediated delactylation of SF3B2 at K280 suppresses tumor growth and fibrosis, enhancing antitumor immunity in cancer.
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