Giredestrant combined with everolimus significantly extends progression-free survival in ER-positive, HER2-negative advanced breast cancer, especially in ESR1-mutated tumors, with a median of 10 months versus 5.5 months.
- 1 on Bluesky
What moved this week
Signals watches every paper JClub indexes for new citations, news coverage and Bluesky conversation. These are the ones that moved — with the app's own brief on each.
- Papers moved
- 294
- Research areas
- 18
- In the news
- 43
- On Bluesky
- 2
- Newly cited
- 0
Rebuilt
Movers
week to 3 Oct 2026
RADAR, a generalist AI trained on over 400,000 abdominal CTs, achieves expert-level diagnosis across 18 structures and 146 findings, with high accuracy and robustness.
- 1 on Bluesky
- 1 opens in JClub
Acetaminophen use during pregnancy is unlikely to cause autism or ADHD, reaffirming previous evidence with no significant association found.
- In the news
A new universal definition of myocardial infarction, blood pressure, and dementia was discussed at ESC Congress 2026, aiming to standardize diagnoses across conditions.
- In the news
Nearly 50% of dementia cases could be prevented by addressing modifiable risk factors, highlighting significant potential for reducing Alzheimer’s and other dementias.
- In the news
Patient-level privacy risks from medical AI are significantly higher than aggregate metrics suggest, with near-perfect attack success rates for individual patients.
- 1 opens in JClub
- Open access
Emeritus professors could significantly enhance academia and society if provided with adequate support, which is currently hindered by ageism.
- In the news
Scarcity of resources enhances intellectual discipline and ingenuity, as demonstrated by how limited access fosters innovative research approaches.
- In the news
Implementing replication of key experiments in scientific publishing is essential to address the ongoing replication crisis and improve research reliability.
- In the news
Bioinformatics has evolved from command-line tools to AI-driven systems, with deep learning models like AlphaFold transforming structural biology and data interaction.
- 1 opens in JClub
- Open access
Machine learning reveals conserved spatial ecotypes in tumor microenvironments across cancers, potentially predicting immune checkpoint therapy response.
- In the news
Sonrotoclax becomes the first BCL-2 inhibitor approved for relapsed or refractory mantle cell lymphoma, showing over 10-fold greater potency than venetoclax.
- In the news
Fasting around chemotherapy improves outcomes in advanced ovarian cancer patients, reducing insulin levels and enhancing treatment success.
- In the news
GLP-1 receptor agonists may prevent progression to stage IV in certain obesity-related cancers, with potential to impact treatment strategies.
- In the news
GRAIL's Galleri MCED test did not significantly reduce late-stage cancers in a large NHS-Galleri trial, with only a modest improvement observed in stage IV cases.
- In the news
Research areas that moved
- Single-cell and spatial transcriptomics10 papers
Cell · Genome Research · Bioinformatics · eLife · GigaScience · Nature · Nature Immunology
- Artificial Intelligence in Healthcare and Education8 papers
Nature · Bioinformatics · Cancer Discovery · Cell · JAMA · Nature Medicine · Science
- CAR-T cell therapy research7 papers
Blood · Cancer Discovery · Cell · Cellular & molecular immunology
- Neuroinflammation and Neurodegeneration Mechanisms6 papers
bioRxiv · Cellular & molecular immunology · eLife · Immunity · Nature Genetics · Neuron
- Lung Cancer Treatments and Mutations5 papers
Cancer Discovery · Nature
- Diabetes Treatment and Management4 papers
Annals of Internal Medicine · BMJ · Cancer Discovery · Cell Metabolism
- Pancreatic and Hepatic Oncology Research4 papers
EMBO Journal · Nature Medicine · Nature Reviews Drug Discovery · New England Journal of Medicine
- Photosynthetic Processes and Mechanisms4 papers
Cell · EMBO Journal · mSystems · Nature Plants
- Genomics and Chromatin Dynamics4 papers
EMBO Journal · Immunity · Nature · Nature Genetics
- Gut microbiota and health4 papers
mSystems · Journal of bacteriology · Virulence
- Neurobiology and Insect Physiology Research4 papers
eLife · EMBO Journal
- SARS-CoV-2 and COVID-19 Research3 papers
eLife · JAMA · mBio
- Virology and Viral Diseases3 papers
Annals of Internal Medicine · mBio · Virulence
- Hepatocellular Carcinoma Treatment and Prognosis3 papers
Gut · Journal of hepatology
- Cancer Genomics and Diagnostics3 papers
Cancer Cell · Cancer Research · The Lancet Oncology
- 3 papers
- Influenza Virus Research Studies3 papers
Virulence · PLOS Computational Biology
- Pharmacology and Obesity Treatment3 papers
BMJ · JAMA · New England Journal of Medicine
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Journals this month
- bioRxiv5569
- medRxiv1738
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4