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Antibiotic Resistance in Bacteria

Moving in Applied and environmental microbiology, bioRxiv, mSystems, medRxiv, Environmental pollution, Environmental research, Nature Reviews Microbiology, eLife.

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Latest in Antibiotic Resistance in Bacteria

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Global dynamics of antibiotic resistance: a modeling study of the spread of endemic and emerging resistance in E. coli
medRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.25.25335519
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Antimicrobial stewardship in LMICs: from paper promises to purpose-driven people.
Nature Reviews Microbiology · 1 Oct 2026 · Journal Article
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Multi-scale analysis of patterns, risks, and mechanisms of edaphic antibiotic resistance genes on the Qinghai-Tibet Plateau: Integrating regional and national perspectives.
Environmental pollution · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42385824
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The role of intracellular ROS in the development of antimicrobial resistance:A convergent mediator linking mutations and horizontal gene transfer.
Environmental pollution · 1 Oct 2026 · Review
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https://jclub.com.au/a/42392292
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Hydrological seasonality shapes antibiotic resistome assembly and dissemination risk in a reclaimed-water-fed urban river.
Environmental research · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42617676
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Klebsiella genus as driver of human disease: from infections to non-communicable disorders.
Nature Reviews Microbiology · 1 Oct 2026 · Review
Klebsiella spp. are major contributors to both infectious diseases and non-communicable disorders, with multidrug-resistant strains posing a significant global health threat.
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Diagnosing antimicrobial stewardship needs in a pluralistic health system in India: Why Local Evidence Must Guide Implementation
medRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.26363886
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Novel Synthetic Polymyxin Variants Inspired by Newly Uncovered Natural Sequences Explored as Potential Antibiotics
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754415
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Spatiotemporal dynamics and stability of multi-kingdom microbial communities in hospital sinks acting as persistent pathogen reservoirs
bioRxiv · 26 Sept 2026 · Preprint
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WITHDRAWN: Blocking IF3N delays bacterial translation initiation
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.14.643242
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Genetic Relationships of Third-Generation Cephem Resistant Escherichia coli in Humans, Dogs and Cattle using a Novel Clonotyping Assay
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363816
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Rapid classification of β-lactamase activity through AI-based structure prediction and electric field analysis
bioRxiv · 25 Sept 2026 · Preprint
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Phage vB_KpnM_NB cocktail synergizing with amikacin in inhibiting persister cells of Klebsiella pneumoniae.
Applied and environmental microbiology · 23 Sept 2026 · Journal Article
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https://jclub.com.au/a/42690138
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Fine-scale structural diversification among closely related Legionella pneumophila isolates from a bath-associated environmental reservoir.
Applied and environmental microbiology · 23 Sept 2026 · Journal Article
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https://jclub.com.au/a/42663473
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Transferable optrA-mediated linezolid resistance in enterococci from high-altitude river sediments of Gilgit-Baltistan, Pakistan.
Applied and environmental microbiology · 23 Sept 2026 · Journal Article
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Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach.
eLife · 23 Sept 2026 · Journal Article
Semapimod inhibits L-leucine uptake in Mycobacterium tuberculosis, reducing bacterial load in infected mice despite no in vitro efficacy.
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https://jclub.com.au/a/42775406
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Klebsiella pneumoniae from fuchka: insights into the genetic diversity, virulence, and antibiogram profile.
Applied and environmental microbiology · 23 Sept 2026 · Journal Article
Nearly half (46.7%) of street food samples in Bangladesh contained Klebsiella pneumoniae, with 37.5% showing multidrug resistance and high virulence gene prevalence.
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https://jclub.com.au/a/42554635
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A functionally selected Acinetobacter sp. phosphoethanolamine transferase gene from the goose fecal microbiome confers colistin resistance in E. coli.
Applied and environmental microbiology · 23 Sept 2026 · Journal Article
A phosphoethanolamine transferase gene from goose fecal microbiome confers high-level colistin resistance in E. coli, highlighting environmental reservoirs of resistance genes.
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https://jclub.com.au/a/42560056
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Chloramphenicol stress triggers oxidative adaptation in Acinetobacter baumannii ATCC19606 devoid of RND efflux pumps AdeAB or AdeIJ.
mSystems · 22 Sept 2026 · Journal Article
Deletion of craA significantly reduces chloramphenicol resistance in Acinetobacter baumannii ATCC19606, highlighting its dominant role among efflux pumps.
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https://jclub.com.au/a/42690054
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Metabolic rewiring of bacterial subpopulations governs polymyxin responses in Acinetobacter baumannii.
mSystems · 22 Sept 2026 · Journal Article
Subpopulations of Acinetobacter baumannii exhibit distinct metabolic responses to polymyxins, with PI-positive cells increasing phosphatidylethanolamine and PI-negative cells upregulating arginine metabolism.
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A One Health perspective on mobile genetic elements and associated antibiotic resistance genes in non-human A. baumannii.
Applied and environmental microbiology · 22 Sept 2026 · Review
Mobile genetic elements in non-human A. baumannii populations harbor resistance genes and suggest circulation between human and non-human environments.
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https://jclub.com.au/a/42770716
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Genomic divergence and phenotypic heterogeneity of Legionella longbeachae reveal a putative novel proinflammatory serogroup with genome reduction and mobilome expansion.
Applied and environmental microbiology · 22 Sept 2026 · Journal Article
A novel Legionella longbeachae serogroup (sg3) exhibits genome reduction to 4.01 Mb yet induces heightened inflammatory responses in human cells.
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Transcriptional regulation drives heteroresistance in Pseudomonas aeruginosa: evidence from genomic and targeted gene expression analysis.
mSystems · 22 Sept 2026 · Journal Article
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Within-host population structure, migration, and parallel adaptive evolution of Pseudomonas aeruginosa in cystic fibrosis lung disease.
mSystems · 22 Sept 2026 · Journal Article
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The host environment rather than biofilm growth activates stress responses and conveys ciprofloxacin tolerance in Staphylococcus aureus
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.07.669083
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Benchmarking of tools for resolving the plasmidome from short-read assemblies for Klebsiella pneumoniae
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.24.666686
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TrbA binds and locks a sliding clamp KorB to repress transcription on multi-drug resistance plasmids.
Journal of bacteriology · 17 Sept 2026 · Journal Article
TrbA binds and locks KorB, a DNA-sliding clamp, to repress transcription on multi-drug resistance plasmids, revealing a conserved clamp-locking mechanism involving multiple regulators.
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Small-molecule inhibitors block NorA efflux by conformational trapping.
Nature Chemical Biology · 16 Sept 2026 · Journal Article
IMP-2380 effectively inhibits the NorA efflux pump in Staphylococcus aureus, restoring antibiotic susceptibility with low-nanomolar potency and structural trapping of the transporter.
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https://jclub.com.au/a/42749827
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From resistance genes to resistance states and enzymatic context-dependence in antimicrobial resistance.
Trends in Microbiology · 16 Sept 2026 · Journal Article
Resistance genes can produce different antimicrobial resistance phenotypes depending on environmental and physiological context, highlighting resistance as a state rather than a fixed trait.
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Does AMR surveillance of surface water reflect AMR in humans? A genomic comparison of ESBL-producing Escherichia coli from surface water, healthy residents, and a clinical facility.
Environmental research · 15 Sept 2026 · Journal Article
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