The abstract is read at the publisher; the summary is JClub's.
Predicted k13 ART-R mutation prevalence in Northern Province, Rwanda, reached 62·2% (95% credible interval 3·9–98·6) in 2024, rising from 0·2% in 2012.
- Why it matters: Sparse molecular surveillance in Africa makes it hard to tell whether increasing Plasmodium falciparum kelch13 signals local emergence or geographic spread, risking ineffective ACT deployment.
- What they did: A systematic review plus spatiotemporal Gaussian process modelling integrated 93 887 k13-sequenced samples from 578 studies across 47 African countries, estimating continuous mutation prevalence with posterior uncertainty.
- The result: The model inferred distinct emergences of k13 R561H in Rwanda, k13 A675V and C469Y in Uganda, and k13 R622I in Ethiopia and Eritrea, enabling high-resolution hot-spot surveillance and prioritised therapeutic efficacy studies.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.