SingPro 2.0 is the first comprehensive proteomics-centric database for single-cell multimodal data, covering 814 studies and 81.5 million cells across diverse tissues and diseases.
Nucleic Acids Research
Oxford University Press · Genomics & Bioinformatics · ISSN 0305-1048, 1362-4962
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Latest in Nucleic Acids Res
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DiCE-Ex uncovers condition-specific regulatory genes by analyzing network centrality shifts, identifying key mediators even without large expression changes.
circRNADisease v3.0 expands to include over 15,390 curated circRNA-disease entries, doubling data volume and enhancing evidence support for understanding circRNA roles in diseases.
VDJdb's 2026 update enhances T-cell receptor recognition data with AI-driven paratope embeddings and structure predictions, improving reliability and coverage.
Alkaline pH enhances Mn2+ sensitivity in Escherichia coli alx riboswitch by remodeling its allosteric structure, enabling combined metal and proton sensing.
Molecular structures of RiboGreen, OliGreen, and PicoGreen reveal they are unsymmetric cyanine dyes with specific benzazolium and quinolinium components, crucial for nucleic acid detection.
A T6SS-associated ADP-ribosyltransferase toxin from Chromobacterium violaceum selectively modifies charged tRNAThr(GGU) anticodon loops to block ACC codon decoding.
DNA methylation by restriction-modification systems modulates gene expression in bacteria through changes in DNA topology, with effects observed in both Streptococcus pneumoniae and Escherichia coli.
CUT&ID enables simultaneous profiling of protein-DNA and protein-protein interactions with high sensitivity from just 1 million cells.
Structural changes in PriA's cysteine-rich region regulate DNA replication restart by responding to lagging strand DNA structure in Escherichia coli.
fDOG-Assembly identifies orthologs in unannotated genomes with accuracy comparable to traditional tools, revealing gene presence missed by conventional annotations.
CRYSPER and CUREIPES reveal cell type-specific RNA splicing and C-to-U editing, uncovering noncanonical splice site usage and enabling inducible protein expression at single-cell resolution.
Approximately 10% of homing endonuclease genes (HEGs) encode active, well-folded proteins capable of cleaving DNA target sites, despite widespread mutations.
Human mitochondrial DNA polymerase γ initiates replication with high stability on RNA primers, enabling strand separation through a unique mechanism involving novel structural elements.
MERGE-RNA accurately predicts RNA secondary structure ensembles, surpassing standard methods with a 20% improvement in recapitulating DMS reactivity data.
Global metagenomics uncovers over 600,000 new protein families, doubling large families and quadrupling smaller ones, vastly expanding known molecular diversity.
Albumin-binding dendrimer-conjugated siRNA achieves durable, widespread gene silencing in the CNS with a single administration lasting up to six months.
APE1 is crucial for mouse embryonic stem cell differentiation, with its absence triggering compensatory DNA repair mechanisms involving NER and TLS pathways.
The MeCP2 MBD-ID module binds DNA and RNA with high affinity, and mutations linked to Rett syndrome weaken RNA and non-methylated DNA interactions, disrupting nucleic acid competition.
Elevated c-di-GMP levels relieve ErsA-mediated repression of key biofilm-related genes in Pseudomonas aeruginosa, linking second messenger signaling to small RNA regulation.
BaCas12a3, a new type V CRISPR effector, specifically cleaves tRNA's 3' CCA end, causing growth arrest without DNA damage in host cells.
m6A modification differentially stabilizes transcripts in planarians, with 72,200 sites influencing cell identity by promoting stability in neoblasts and destabilization in differentiated cells.
Engineered DNMT3A enables live-cell mapping of methylation activity, revealing distinct roles at genomic features in mammalian embryonic stem cells.
2'-O-methylation of mRNA selectively inhibits translation initiation at upstream AUG and near-cognate codons, enhancing canonical ORF expression in human transcriptomes.
DNA damage causes long-range structural and dynamic changes in duplex DNA, with modifications like abasic sites and nicks significantly altering FRET signals across the molecule.
iPscDB integrates 4.69 million plant single-cell transcriptomes and 288,139 curated markers across 38 species, simplifying complex data analysis for diverse researchers.
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Moving areas, week to 3 Oct 2026
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