PmiREN3.0: a multi-omics integrated and AI-assisted encyclopedia for plant microRNA research.

PmiREN3.0 expands plant miRNA coverage from 179 to 340 species/subspecies and increases high-confidence miRNA loci from 39,751 to 87,667 using standardized sRNA-seq annotation.

• Why it matters: Plant miRNA studies need to integrate large, heterogeneous datasets and support faster knowledge exploration, but prior encyclopedia versions limited breadth and multi-omics integration.
• What they did: The team updated Plant MicroRNA Encyclopedia with the same workflow and criteria, re-annotating 5319 sRNA-seq datasets and adding six modules for multi-omics features.
• The result: The new miRai+ AI knowledge service, evaluated at 0.910 relevance, 0.965 faithfulness, and 0.906 factual correctness, enables integrated, AI-assisted querying for plant miRNA research.

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