A viroid-like RNA, TsvlRNA1, can autonomously replicate and transfer among Trichoderma species, influencing their biocontrol ability against plant pathogens.
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- 1 cites
mBio
American Society for Microbiology · Microbiology & Mycology · ISSN 2150-7511
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Powassan virus infection causes age-dependent neuroinflammation and persistent Alzheimer’s-like APP/Aβ accumulation in mouse brains, with 50-week-old mice showing significant neurodegenerative changes.
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Human transferrin receptor 1 (hTfR) acts as a critical entry co-receptor for parvovirus B19, facilitating viral internalization into human erythroid progenitor cells.
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A small molecule targeting ribosomal protein S5 enhances mycobacterial translational fidelity without slowing protein synthesis, countering antibiotic tolerance.
Two closely related β-1,2-xylosyltransferases are essential for cryptococcal glycan synthesis, with Cxt1 and Cxt2 responsible for all xylose addition to O-glycans in Cryptococcus neoformans.
MAVS preserves mitochondrial import and independently restricts RNA virus replication, including SARS-CoV-2, by maintaining mitochondrial integrity without relying on interferon signaling.
Chicken DDX60 enhances dsRNA analog-induced IFN-β signaling by synergizing with MDA5 in the absence of RIG-I in chickens.
TgDDP, a novel DIX domain protein, is essential for daughter cell formation during Toxoplasma gondii endodyogeny, with depletion blocking parasite replication.
A universal, scalable framework enables efficient genetic code expansion across five diverse bacterial species, surpassing previous organism-specific limitations.
Monoclonal antibodies targeting the Junín virus glycoprotein show broad reactivity and protect mice and guinea pigs, with five antibodies significantly reducing viral loads in vivo.
Ex vivo human vascular tissue effectively models bunyavirus-induced endothelial injury, revealing viral infection and tissue damage with significant implications for antiviral testing.
Drug-resistant Mycobacterium tuberculosis exhibits condition-dependent metabolic vulnerabilities that influence its adaptation and susceptibility to antibiotics.
FlhG, a MinD-like ATPase, spatially regulates flagellar patterning and cell division in Borrelia burgdorferi, ensuring proper motility and cellular architecture.
Pangolin-derived sarbecoviruses show significantly reduced pathogenicity and transmissibility compared to SARS-CoV-2 in human ACE2 transgenic hamsters, with MpCoV-GD causing lung damage similar to SARS-CoV-2.
A single dose of CI-679-attenuated Plasmodium berghei sporozoites induces IL-15-dependent liver CD8(+) tissue-resident memory T cells, achieving robust malaria protection in mice.
A novel oxygen-dependent pigment produced by Streptococcus pyogenes was identified, with production linked to specific metabolic pathways and serotypes, highlighting a new aspect of its biology.
Two decades of in vivo coral microbiome manipulation research have identified key probiotic taxa and revealed significant methodological challenges.
HCMV US30 promotes viral replication by inducing mitochondrial fission and apoptosis through TMED10 and DRP1, with US30-dependent effects accounting for viral dissemination.
SepIVA activates mycobacterial divisome and is inhibited during DNA damage, with its interaction with FtsQ blocked to prevent cell division under stress.
Yersinia pseudotuberculosis exhibits a distinct transcriptional response to macrophage-released nitric oxide and itaconate, with peripheral bacteria primarily activating nitrosative stress genes.
Psc1, an RNA-binding protein in Cryptococcus neoformans, suppresses CO2 tolerance by sequestering key mRNAs when unphosphorylated, impairing growth under high CO2 conditions.
Single-cell analysis reveals that StkP kinase activity is constant, but phosphorylation of DivIVA varies dynamically during Streptococcus pneumoniae cell division.
CRISPR transposition and overexpression (CRISPRtOE) enables targeted, genome-scale gene upregulation in Proteobacteria, including Escherichia coli and Zymomonas mobilis.
Methanotrophs dissipate up to 60% of substrate energy as heat, with heat yields surpassing other aerobic microbes, indicating their potential for methane mitigation and energy recovery.
Experimental models and clinical studies reveal distinct relapse mechanisms in tuberculosis, with clinical relapse driven by non-replicating bacteria and experimental relapse by residual replicating bacteria.
DHX9 resolves R-loops during HBV transcription, promoting viral replication and revealing a potential antiviral target.
Craig Venter revolutionized microbiology by sequencing the first bacterial genome and pioneering the integration of genomics and synthetic biology into vaccinology.
CT226 effector protein of Chlamydia trachomatis recruits a host multiprotein complex via direct binding, modulating inclusion size and bacterial progeny production.
- Open access
MAIT cells exhibit tissue-dependent responses to S. aureus and show variable sensitivity to HlgAB toxin, with tonsillar MAIT cells being notably resistant.
- Open access
Yersinopine is a primary zinc acquisition system in Yersinia pseudotuberculosis, essential for growth under zinc-limited conditions, unlike in Yersinia pestis where it is inactive.
- Open access
DcrB acts as a molecular safeguard in Escherichia coli by promoting Lpp maturation and preventing toxic inner membrane-peptidoglycan linkages, especially under stress conditions.
- Open access
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Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4