Machine learning-guided design yields Nb-Si alloys with fracture toughness of 18.92 MPa·m^1/2 and high-temperature strength of 322 MPa at 1250°C, surpassing previous alloys.
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Nature Communications
Nature Portfolio · General Science & Medicine · ISSN 2041-1723
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MYDGF drives retinal angiogenesis through Gαi1/3-Gab1-Akt-mTOR signaling, promoting both pathological and physiological vessel growth in mice and humans.
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Dense optical genome mapping achieves chromosome-scale assembly of yeast genomes, revealing structural variations and repetitive regions up to 500 kbp in size.
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Cross-border electricity tariffs above 55% on Ontario and 90% on Quebec nearly eliminate imports, increasing emissions and risking grid reliability in North America.
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Multilayer MEG source modeling achieves depth-resolved laminar inference in humans, revealing laminar activation patterns aligned with cortical motifs.
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Programmable DNA protonuclei reveal that environmental factors like confinement and viscoelasticity critically influence FUS protein phase separation, with a significant impact on disease-related transitions.
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Exact random-matrix theory reveals giant fluctuations in wavefront shaping enhancement factors in strongly scattering media, surpassing traditional predictions as input control increases.
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Sphingolipids localize within Chlamydia trachomatis nucleoids and mark early developmental transitions, with sphingomyelin linked to DNA condensation in elementary bodies.
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Viral delivery of PRPF31 restores splicing, cellular function, and visual activity in patient-derived retinal cells, even in mature stages, offering a promising therapy for RP11.
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Multiband topological heterojunctions on the surface nanoscale axial photonics platform reveal complex topological phases with up to 21 coupled microresonators.
DNA shape features at promoters and origins of replication guide INO80 chromatin remodeler binding and activity, with 1D searches and intersegmental transfers facilitating nucleosome positioning.
Pulsed electromagnetic fields activate a peripheral interoceptive pathway to suppress sympathetic neuropeptide Y, preventing stress-induced osteoporosis in mice.
Independent evolution of flight-related features in microraptorine dinosaurs and birds is supported by osteohistological evidence, with about 30% of traits convergently acquired.
Novel H5N1 influenza hemagglutinin variants in a human patient show significantly reduced sialoside binding, with some variants exhibiting almost no affinity.
N(1)-methylpseudouridine increases +1 frameshifting on UUUC motifs in mRNA vaccines, affecting translational fidelity and antigenicity.
Whole-genome sequencing identifies pathogenic germline alterations in 7.7% of childhood leukemia cases, enabling tailored clinical management in a nationwide cohort.
A nearly complete Early Cretaceous eutriconodontan mammal exhibits polyphyodonty, the only known Mesozoic mammal with multiple generations of teeth at some loci.
Nodamura virus B2 protein boosts self-amplifying RNA activity by suppressing intracellular antiviral responses without impairing immune signaling.
Cell-derived lactate induces rapid, localized hydrogel formation with up to 5 kPa stiffness in tumour models, enabling spatial control of matrix remodelling.
Engineered Escherichia coli with an orthogonal energy system enables growth and chemical production from CO₂ and methanol, doubling growth rate and high biomass yield.
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Intracrystalline chain diffusion significantly influences the non-linear mechanics of PEO, with stress dependence on rate and temperature, unlike PCL which remains rate-independent.
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The human Mic60-Mic19 subcomplex forms a dynamic tetrameric structure that acts as a diffusion barrier at mitochondrial crista junctions, with a key role in mitochondrial regulation.
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