Experience modifies the synaptome architecture in the developing and adult mouse brain.

Environmental enrichment and monocular visual deprivation reconfigure excitatory synapse populations across more than one hundred regions of the mouse brain, reshaping synaptome architecture.

• Why it matters: It is unclear how sensory input and experience alter the brain’s spatial and temporal organization of excitatory synapses.
• What they did: The study compared synaptome architecture after environmental enrichment or monocular visual deprivation, mapping excitatory synapse types and subtypes across many brain regions.
• The result: Experience-dependent reconfiguration during development and adulthood is similar, aligns with protein turnover and connectome architecture, and supports a population-selection model of synaptome adaptation.

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