The Lancet
Elsevier BV · General Science & Medicine · ISSN 0140-6736
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Most-favoured-nation pricing models could reduce US Medicare spending by approximately $6.4 billion annually for 195 brand-name drugs.
PAD affects over 300 million people worldwide and causes severe individual and societal impacts, including chronic pain, disability, and high-risk adverse events.
Adding atezolizumab to SBRT does not improve overall survival in high-risk, early-stage non-small-cell lung cancer, with 2-year survival at 82% in both groups.
Peripheral arterial disease has a 5-year mortality rate of 30-50%, surpassing severe cancer and myocardial infarction, highlighting its critical global health impact.
Advances in PAD management emphasize medical therapy and minimally invasive procedures, with revascularization reserved for severe cases, aiming to reduce limb loss and improve quality of life.
Physiotherapist-led care reduces emergency department stay by 1 hour for musculoskeletal patients, without safety concerns, and is highly cost-effective.
Implementing wealth redistribution policies could prevent up to nearly 30 million deaths by 2030 in low-income countries facing aid cuts.
An 8-week sofosbuvir-velpatasvir regimen is non-inferior to 12 weeks for treating non-cirrhotic chronic hepatitis C, achieving over 98% SVR12 success.
Orforglipron demonstrates non-inferior cardiovascular safety compared to insulin glargine in adults with type 2 diabetes at increased cardiovascular risk, with a hazard ratio of 0.84.
Radial and patchy hyperintensities in brainstem MRI are key features for diagnosing neuroborreliosis, as shown in a 59-year-old patient with atypical symptoms.
Retatrutide reduced bodyweight by up to 18.8% in adults with obesity and type 2 diabetes over 80 weeks, outperforming placebo in a phase 3 trial.
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