Lysosomal lipid and protein changes in the aging brain show increased myelin components and disrupted sphingolipid breakdown, especially in microglia, indicating dysfunction.
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Cell Reports
Cell Press · Cell & Molecular Biology · ISSN 2211-1247
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YdzF, a non-canonical regulator, controls bacterial nanotube formation in Gram-positive bacteria through YmdB-dependent flagellar gene regulation.
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Protein interaction networks in a mouse tauopathy model undergo significant, phosphorylation-dependent remodeling, with over 20 key complexes showing dynamic changes during disease progression.
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Engineered extramedullary bone model reveals systemic inflammation increases metastatic reactivation by over 50% in dormant breast cancer cells.
SMF-1 pilus forms antiparallel bundles that facilitate rapid biofilm initiation in Stenotrophomonas maltophilia, revealing a unique structural mechanism for bacterial colonization.
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USP-48 is essential for insulin-mediated lifespan extension in C. elegans by regulating mitochondrial stress responses and histone H2B deubiquitination.
Embryonic mouse skeletal motor neurons lose transcriptional diversity and re-diversify into adult subtypes to support functional maturation, with 70+ embryonic subclusters consolidating into distinct adult identities.
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Vpu prevents antibody-dependent cellular phagocytosis of HIV-infected cells by counteracting tetherin, reducing surface virion accumulation and immune recognition.
PNPLA7 is essential for phosphatidylcholine turnover, with its deficiency causing muscle fiber thinning, mitochondrial abnormalities, and reduced endurance in mice.
Long-term ART-suppressed SIV infection in rhesus macaques causes bi-phasic immune changes, including initial interferon responses and later TGF-β and NF-κB signaling disruptions.
Migratory type 1 dendritic cells are key drivers of effective CD8+ T cell priming in tumor environments, outperforming lymph node-resident counterparts with higher cross-presentation capacity.
MiniLFMv2 enables high-resolution, large-volume, deep neuronal imaging at 30 Hz in freely moving mice, capturing activity from hundreds of parietal cortex neurons.
Pioneer transcription factor ETS1 primes histone activation and drives 3D genome reorganization during osteoblast differentiation, with B-to-A chromatin shifts pre-marked in pre-osteoblasts.
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Chikungunya virus relies on tetraspanins CD63, CD9, and CD151 to replicate in human synovial fibroblasts, with silencing reducing virus production by up to 100%.
Potent neutralizing antibodies target three distinct vulnerable sites on EBV gp350, with one in the D3 domain conferring post-attachment neutralization.
Cognate antigen recognition enables antigen-specific Tregs to eliminate CD4 effector T cells via perforin, granzyme B, and Bim, revealing a precise cytotoxic mechanism.
Activation of TREM2 with single-domain antibodies 10C11 and 10E12 improves cognition and reduces pathology in 5×FAD mice, with 10E12 decreasing Aβ plaques by targeting microglia.
LiP-MS uncovers a feedback loop where tomato UDP-glucosyltransferases regulate bioactive jasmonate homeostasis by glucosylating jasmonic acid into JA-glucosyl esters.
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