The abstract is read at the publisher; the summary is JClub's.
Piezo1 in Gli1-lineage periodontal mesenchymal stromal cells senses occlusal force and drives a PGE2-dependent brain-bone interoceptive circuit that regulates mandibular bone homeostasis.
- Why it matters: It is unclear whether craniofacial bone uses interoceptive control to monitor mechanical state and maintain homeostasis, especially under reduced loading.
- What they did: Mechanical loading activates a YAP–Gli1 transcriptional complex to promote COX-2 expression and PGE2 production, engaging trigeminal pathways and altering ventromedial hypothalamic activity and sympathetic output.
- The result: Disrupting the circuit during occlusal hypofunction elevates sympathetic tone, increases osteoclast activity, and impairs type H vessel formation; Piezo1 deletion in Gli1-lineage MSCs largely abolishes these occlusal-force effects.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.