Machine learning reveals conserved spatial ecotypes in tumor microenvironments across cancers, potentially predicting immune checkpoint therapy response.
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Cancer Immunotherapy and Biomarkers
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CRISPR screens reveal Dusp5 and Zfp219 as key regulators of age-related T cell dysfunction, with Zfp219 ablation improving tumor clearance in aged mice.
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TLR9 agonists enhance adoptive T cell therapy by activating a B cell-CD2 costimulatory pathway, leading to improved tumor control and T cell function.
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Immune checkpoint inhibitor combinations have become the standard first-line systemic therapy for HCC, significantly improving survival and response rates over previous treatments.
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A spatial atlas of muscle-invasive bladder cancer uncovers lineage-specific vulnerabilities and immune structures across 22 tumors.
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Mismatch repair-proficient Colorectal Cancer evades immune attack through intrinsic secretome-driven suppression, despite identical antigen presentation in 25 words.
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p97 is essential for late-stage thymocyte positive selection, with its loss causing a severe blockade in CD8+ lineage commitment and thymocyte development.
Intratumoral T cell activation can eradicate tumors without tumor-specific T cell receptors, relying on paracrine signaling and innate immune responses.
Five-year survival rates with neoadjuvant immune checkpoint inhibitors reach up to 87.5% in melanoma, significantly outperforming targeted therapies and combination regimens.
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Crumblr enhances detection of cell composition differences by increasing statistical power 2- to 3-fold in single-cell RNA-seq data analysis.
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Mucosal CAR-T cells persist and cause inflammatory remodeling in enterocolitis, with 10 patients showing severe mucosal dysregulation after BCMA CAR-T therapy.
Targeting ZMYND8 enhances IL-2 signaling, promoting effector-like CD8+ T cell responses and improving antiviral and antitumor immunity.
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CD40 activation in B cells enhances anti-tumor immunity by promoting CD8+ T cell infiltration and cytotoxic function in high-mutation tumors.
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γδ T cells infiltrate small cell lung cancer (SCLC) tumors and predict improved responses to immunotherapy, highlighting their potential as therapeutic targets.
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Coordinated cellular programmes involving exhausted T cells, regulatory T cells, memory B cells, and macrophages predict responses to neoadjuvant PD-L1 blockade in ESCC.
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γδ T cell-engaging BiTEs demonstrate potent activity against small cell lung cancer, overcoming limitations of traditional CD8+ T cell responses.
Cancers evade T cell detection by restricting presentation of p53 neoantigens, with 70% of hotspot mutations avoiding display in tumors.
Combining radiotherapy with immunotherapy can enhance systemic antitumor immunity, but success depends on balancing local control with immune activation, with some approaches showing promise in specific cancers.
- Open access
Five conserved malignant B cell archetypes, including a quiescent memory B cell-like type, predict clinical outcomes in large B cell lymphomas, with Archetype 4 linked to poor survival.
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Combining cyclophosphamide with immune checkpoint blockade expands effector CD8+ T cell clones, delaying tumor progression in multiple cancer models.
Inhibiting PPM1D disrupts mitochondrial integrity, activates cGAS-STING signaling, and enhances antitumor immunity in hepatocellular carcinoma models.
AI-driven integration of multi-modal single-cell genomics and reverse vaccinology enables de novo design of personalized multi-epitope cancer vaccines, advancing immunotherapy.
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