Astrocytes activate the CD40 pathway to propagate neuroinflammation, revealing a new role beyond traditional immune cells in the brain.
Science Immunology
American Association for the Advancement of Science · Immunology & Inflammation · ISSN 2470-9468
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RORC-expressing dendritic cells are enriched in malignant ascites and metastases, indicating a potential role in advanced cancer progression.
Migratory dermal γδ T cells orchestrate lung immune responses and prevent tissue damage during helminth infection, with IL-17 production linked to their migration.
Decidual fibrinoid-associated neutrophils (dFANs) secrete MMP-9 and promote trophoblast invasion, supporting invasive placentation at the maternal-fetal interface.
Nanobodies targeting MR1-5-OP-RU complexes effectively inhibit MAIT cell responses and enable T cell-mediated killing of infected and tumor cells.
In vitro, human naive B cells can be converted into GCB-like cells exhibiting key features of natural germinal center B cells, including ongoing SHM, with 100% efficiency.
In vivo CRISPR screens reveal SLC1A5 as a key metabolic barrier limiting CD8 T cell responses in tumors, impacting immunotherapy outcomes.
AMnESTI restores aged lung immunity to enable complete heterosubtypic protection by influenza vaccines in elderly mice.
Neutrophils adapt their motility via Rho-dependent contractility to navigate confined capillaries, preventing occlusion and maintaining blood flow during inflammation.
Variant-specific B cells in SARS-CoV-2-infected dogs complement existing immune memory, enhancing neutralization of diverse viral variants.
IgG1-expressing plasma cells outcompete IgM cells by enhanced antigen presentation and signaling, leading to greater bone marrow longevity and immune response efficiency.
Tissue mitochondrial activity determines macrophage pool size through regulation of CSF1 availability in oxidative tissues.
Type I IFN-induced IFN-γ primes monocytes to provide systemic bacterial protection during intestinal helminth infections, revealing a novel immune pathway.
Platelet-derived serotonin causes age-related lung damage in SARS-CoV-2 infection, with 50% reduction in respiratory failure when blocked in mice.
Androgen signaling through sympathetic neurons reduces allergic pulmonary inflammation, with male mice showing a 50% decrease in inflammation severity.
CAR T cell-derived TNF is a key early driver of cytokine release syndrome severity, influencing disease progression and lethality in mouse and humanized models.
Dendritic cell autophagy and neutrophil activity restrict intratumoral STING immunotherapy efficacy, with neutrophil depletion improving tumor control in mice.
Fusion of IgG antibodies to albumin significantly reduces transplacental transport, decreasing fetal exposure in mouse and human placental models.
Oxidized lipids, including enzymatically and nonenzymatically generated forms, regulate inflammation by influencing immune responses and tissue homeostasis.
A heterozygous CDC42 T43I variant enhances pyrin inflammasome activation, revealing a new regulatory mechanism in autoinflammatory responses.
Intranasal FluMist vaccination induces measurable upper airway humoral memory in adults, as shown by longitudinal nasopharyngeal swab analysis.
CDC42 binds to pyrin B30.2 domain, revealing a new mechanism regulating pyrin inflammasome activation.
A genotype-first approach identified 265 MEFV variants, revealing multiple pathways of pyrin inflammasome activation and clarifying mechanisms underlying autoinflammatory diseases.
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