A telomere-to-telomere human genome benchmark achieves 99.4% accuracy, adding 701.4 Mb of previously missing autosomal and sex chromosome sequences.
- 35 cites
Genomics and Phylogenetic Studies
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Long-read genome analysis of 103 bat species reveals a revised phylogeny and European origin of bats, dating back to the late Palaeocene with 26 ancestral chromosomes.
- Open access
- 1 cites
Integrating enzymatic DNA synthesis, assembly, and MutS-based error correction into a continuous pipeline enhances fidelity and scalability for gene construction.
- Open access
ISChip enables absolute quantification of 183 insertion sequences across diverse environmental samples with high sensitivity, revealing key hotspots in the One Health continuum.
Metabolic profiling reveals 269 tissue-specific metabolites, with 230 upregulated in root-associated endophytes of Thymus vulgaris, highlighting distinct chemical diversity.
A generalized lineage nomenclature system enables scalable viral genomic surveillance, exemplified by defining 21 chikungunya virus lineages across 8 founding lineages.
- Open access
A machine-learning framework predicts strain-level phage-host interactions across diverse bacteria with AUROC up to 0.94, independent of phylogenetic constraints.
- Open access
GBZ-base and GAF-base enable efficient, disk-based pangenome analysis with smaller file sizes and rapid subgraph and alignment extraction.
- Open access
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