Macrophage-induced senescent cancer-associated fibroblasts drive 78% chemoresistance in colorectal cancer via SASP factors IL6 and CXCL12.
Immune cells in cancer
Moving in Cell Reports, Nature Immunology, bioRxiv, Cancer Research, Cancer Discovery, Cellular & molecular immunology, Blood, Cancer Cell.
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Latest in Immune cells in cancer
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IL-1α drives expansion of SLC2A1highSPP1highIFNlow myeloid cells, promoting immune escape and malignant transformation in pre-cancerous head and neck lesions.
Neutrophils limit immunosuppressive macrophage polarization in PDAC liver metastases through trogocytosis, reducing metastatic progression by 50%.
- Open access
Neutrophil-integrated syncytial CAR macrophages significantly enhance tumor infiltration and therapeutic efficacy, reducing tumor burden and preventing recurrence in mouse models.
LPL-positive endothelial cells promote T-cell homing and liver metastasis regression by enhancing antigen presentation and immune targeting.
- Open access
Senescent-like neutrophils expressing BHLHE40 promote immunosuppressive and angiogenic niches in colorectal cancer liver metastasis, correlating with poor prognosis.
Uterine monocytes play dual roles in tissue remodeling and inflammation, with their functions fluctuating across reproductive cycle stages, impacting tissue homeostasis.
- Open access
IL-17D reprograms CD93(+) antigen-presenting cells in glioblastoma, extending survival by substantial reorganization of the tumor immune environment.
Cancer-associated extracellular vesicles and particles cause widespread systemic dysfunction, affecting multiple organs and contributing to disease progression and host mortality.
Blocking the m(6)Am methyltransferase PCIF1 in macrophages reduces colitis severity by enhancing ECM remodeling and protecting enteric neurons, with a 50% decrease in inflammation.
Exercise reduces stromal fibroblasts and inflammatory signals in pancreatic cancer, with a 50% decrease in αSMA+ cells linked to microbial metabolites.
- Open access
Acetate inhibits esophageal squamous cell carcinoma growth by activating an ACSS2-dependent H2A.Z acetylation pathway, with low acetate and ACSS2 linked to poor prognosis.
- Open access
ACLY palmitoylation driven by palmitic acid enhances macrophage histone acetylation, suppressing hepatocellular carcinoma progression by reprogramming the tumor microenvironment.
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Tumor-associated macrophages (TAMs) are the main nonmalignant cells accumulating albumin in tumors, with FcRn-mediated uptake crucial for their maturation and immunotherapy response.
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Inhibiting TET2 reprograms myeloid cells to enhance radiotherapy and suppress metastasis, improving outcomes in lung cancer models.
Immunosuppressed non-melanoma skin cancers show significant spatial and functional changes in macrophage and immune cell organization, with reduced macrophage densities and altered niches.
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