A novel immunomodulatory CAF population expressing CHL1 promotes Treg recruitment and tumor immune suppression in lung cancer.
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Nature Immunology
Nature Portfolio · Immunology & Inflammation · ISSN 1529-2908, 1529-2916
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HLA-C2 allotypes and KIR2DL1+ NK cells significantly reduce HIV-1 reservoir cell persistence during long-term antiretroviral therapy, with a notable impact on intact proviruses.
AMBRA1 allosterically activates NLRP3 by destabilizing its autoinhibited conformation, promoting inflammatory responses in mouse disease models.
Intestinal epithelial cells presenting cytosol-delivered bacterial antigens program robust barrier immune memory, with significantly enhanced responses compared to bacterial retention.
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Metastasis promotes tumor immunogenicity by producing migrasomes that deliver antigens and activate immune responses, reducing metastatic growth.
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Neutrophil-integrated syncytial CAR macrophages significantly enhance tumor infiltration and therapeutic efficacy, reducing tumor burden and preventing recurrence in mouse models.
Intratumoral T cell activation can eradicate tumors without tumor-specific T cell receptors, relying on paracrine signaling and innate immune responses.
Uterine monocytes play dual roles in tissue remodeling and inflammation, with their functions fluctuating across reproductive cycle stages, impacting tissue homeostasis.
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Single-cell genomics reveals diverse pathogenic immune cell subsets in rheumatoid arthritis, paving the way for targeted therapies.
Monocyte-derived galectin-1(hi) cells are essential for generating and maintaining lung tissue-resident memory CD8+ T cells after influenza infection, with over 4 months persistence.
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ID2 promotes cDC1 development by antagonizing E proteins at Zeb2 enhancer E-boxes, rescuing cDC1 differentiation in Id2-deficient mice.
Deletion of a distal IRF4 regulatory element prevents cytokine-driven destabilization of human T reg cells, maintaining their suppressive identity and function.
Persistent expansion of alloreactive T cell clones and phenotypic plasticity drive severe graft-versus-host disease in human transplant recipients.
ANKRD11 deficiency in CD8+ T cells boosts antiviral and antitumor immunity, increasing effector function and tumor regression in chronic infection and cancer.
Fibro-inflammatory remodeling in bone marrow is a defining feature of clonal hematopoiesis of indeterminate potential, with a significant expansion of fibroblasts and extracellular matrix changes.
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