Gut
BMJ · Clinical Medicine · ISSN 0017-5749, 1468-3288
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The global prevalence of disorders of gut-brain interaction remains consistent at around 41% using Rome V criteria, confirming high worldwide burden.
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Longitudinal circulating tumour DNA testing predicts recurrence in colorectal cancer with 79.9% sensitivity, enabling earlier interventions beyond 12 months post-surgery.
Altered regulatory T cell function and abundance are central to autoimmune liver diseases, with significant differences observed between peripheral blood and liver tissue.
Disrupted circadian rhythms linked to metabolic and gastrointestinal diseases can be mitigated by targeted therapies that restore biological clock alignment.
Hypothermic oxygenated and normothermic machine perfusion reduce neutrophil-driven inflammation and promote immune regulation after liver transplantation, with HOPE showing faster immune normalization.
European consensus establishes standardized guidelines for managing symptoms after oesophago-gastric cancer surgery, covering 8 key statements and 13 recommendations.
Consensus recommends designing HCC clinical trials with specific patient selection, endpoints, and comparator arms to evaluate systemic therapies effectively in surgical and locoregional settings.
Metastatic pancreatic ductal adenocarcinoma exhibits high molecular heterogeneity and evades detection, contributing to its status as one of the deadliest cancers with poor patient outcomes.
Hepatocyte-derived butyrylcholinesterase reduces liver fibrosis by regulating acetylcholine levels and muscarinic receptor signaling, with deficiency increasing fibrosis severity.
Piezo2-expressing neurons and glial cells initiate early macrophage activation, driving inflammation in postoperative ileus in mice.
Multi-omics analysis identifies a lipid-rich, immune-infiltrated subtype of steatohepatitic hepatocellular carcinoma with an AUC of 0.909 for diagnosis.
Ninety percent of patients with Barrett-related dysplasia and cancer were diagnosed without prior endoscopic surveillance, highlighting gaps in early detection.
Gut microbiome structural and functional profiles predict 90-day hospitalisation risk in cirrhosis with an AUC of 0.84, outperforming clinical models.
Coordinated cellular programmes involving exhausted T cells, regulatory T cells, memory B cells, and macrophages predict responses to neoadjuvant PD-L1 blockade in ESCC.
- Open access
Over 50% of strictly defined immune tolerant chronic hepatitis B patients transition to immune active disease within five years, especially those with high-normal ALT levels.
- Open access
Eosinophilic gastritis affects the stomach with dense eosinophilic infiltration and lacks approved long-term treatments, highlighting a significant unmet medical need.
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Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4