Chronic kidney disease in cirrhosis: a study of inpatients from a global perspective.

In 7,040 hospitalized cirrhosis patients worldwide, chronic kidney disease is present in 18.17%, with the highest prevalence in high-income countries.

• Why it matters: CKD is increasing globally, but its frequency in cirrhosis and its effect on inpatient outcomes across different economic settings are not well quantified.
• What they did: The Chronic Liver Disease Evolution and Registry for Events and Decompensation consortium prospectively enrolled non-electively admitted patients from 127 sites, comparing CKD+ versus CKD- using enrollment GFR and clinical outcomes.
• The result: CKD+ patients had lower median enrollment GFR (32 (21, 44) vs 88 (63, 117) mL/min/1.73 m²) and more complications, including AKI (59.4% vs 27%), and CKD was linked to higher in-hospital and 30-day postdischarge mortality (both p<0.0001).

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