A single dose of VERVE-102 achieved up to 88% reduction in PCSK9 and 62% decrease in LDL cholesterol in adults with hypercholesterolemia.
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- 32 cites
Lipoproteins and Cardiovascular Health
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Atorvastatin reduces major cardiovascular events by 30% in adults aged 70 and older but does not extend disability-free survival over nearly six years.
The 2025 VA/DoD lipid management guideline recommends more intensive therapy for high-risk patients, including combination treatments and new risk assessment tools.
A zebrafish phenotypic drug screen identified seven compounds, including enoxolone, that lower ApoB-containing lipoproteins, highlighting HNF4α as a key regulator.
- Open access
Familial hypercholesterolemia affects both homozygous and heterozygous individuals, requiring tailored assessment, diagnosis, and management strategies.
The 2023 PREVENT-ASCVD equations reclassify cardiovascular risk more accurately than the 2013 PCEs in NHANES data, affecting millions of adults.
Over 50% of US adults with atherosclerotic cardiovascular disease have LDL-C levels above 2026 guideline targets, highlighting significant gaps in lipid management.
The 2026 dyslipidemia guideline increases US primary prevention statin eligibility to 87.5 million adults, mainly in lower-risk, younger populations.
The 2026 ACC/AHA guideline provides comprehensive recommendations for managing dyslipidemia to reduce cardiovascular risk.
A single dose of VERVE-102 achieved up to 88% reduction in PCSK9 and 62% decrease in LDL cholesterol in adults with hypercholesterolemia.
- Open access
- 32 cites
Adding tirzepatide to standard care reduces one-year risk of major adverse cardiovascular events by 1.4% in patients with type 2 diabetes and established atherosclerotic disease.
- Open access
- 1 cites
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