Physical activity improves cardiometabolic health and enhances weight loss outcomes when combined with other interventions, but alone rarely achieves 5% weight loss in Homo sapiens.
- 12 cites
Circulation
Lippincott Williams & Wilkins · Clinical Medicine · ISSN 0009-7322, 1524-4539
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The 2026 AHA/ACC/ADA/ASN guideline updates and expands management strategies for cardiovascular-kidney-metabolic syndrome, targeting clinicians caring for affected patients.
- 39 cites
The Second Universal Definition of Heart Failure (2026) standardizes classification into reduced, preserved, and improved ejection fraction categories, moving beyond rigid cutoffs.
- 5 cites
Sirolimus-eluting balloon with provisional stenting is noninferior to systematic drug-eluting stent implantation for target vessel failure at 1 year in de novo coronary lesions.
- 13 cites
Latest in Circulation
Newest first · last 60 days
Undertreatment of antithrombotic therapy increases adverse outcomes, including ischemic stroke and mortality, in patients with thrombotic conditions, affecting over 50% of cases.
Tocilizumab reduces the 2-year incidence of major adverse cardiovascular events by 4.3% in patients with giant cell arteritis compared to methotrexate.
Epigenome-wide analysis reveals 1253 CpGs linked to AAA, with 143 showing potential causal roles, highlighting inflammatory pathways and blood lipids as key factors.
METTL7A, a mechanosensitive internal m7G methyltransferase, reduces atherosclerosis by stabilizing anti-inflammatory endothelial transcripts, with a 50% reduction linked to disease progression.
SMOC-1, a secreted calcium-binding protein, is significantly upregulated in AMI patients with cardiac rupture and protects against rupture by promoting fibrosis.
Blocking PD-1 in CD8(+) T cells worsens pressure overload-induced heart failure by increasing mitochondrial damage and cardiomyocyte death, with a 2.5-fold increase in severity.
Pulsed field ablation (PFA) for atrial fibrillation shows a 0.36% higher 30-day stroke or TIA risk compared to radiofrequency ablation (RFA) in a large US registry.
Hospital Comprehensive Stroke Center designation is independently associated with higher reported stroke rates after TAVR, affecting performance assessments for 8 of 153 hospitals.
Advances in imaging, targeted therapies, and understanding autoinflammatory mechanisms have transformed pericarditis management from symptom control to personalized, mechanism-based care.
The 2026 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM guideline offers updated perioperative cardiovascular management recommendations for adult noncardiac surgery patients, replacing the 2014 version.
Myeloid cell expansion directly contributes to right ventricular dysfunction in HFpEF, with a 40% increase in leukocyte infiltration observed in affected mice and humans.
Primary Raynaud phenomenon affects 2-3 times more women in their teens, with a benign course, while secondary Raynaud often occurs later and can cause tissue loss.
LAPTM4A enhances mTORC1 signaling, promoting pathological cardiac hypertrophy in mice and humans, with deletion reducing hypertrophy and fibrosis.
Coronary computed tomography angiography-derived fractional flow reserve (FFR-CT) predicts future cardiovascular events with significant accuracy, especially below a threshold of 0.67, in a large nationwide cohort.
Extravascular implantable cardioverter defibrillators (EV-ICDs) show 89.1% one-year freedom from major complications in a large global cohort.
Sotatercept reduces right ventricular contractility by 24 weeks in pulmonary arterial hypertension patients but maintains RV-PA coupling and improves overall right heart mechanics.
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Moving areas, week to 3 Oct 2026
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