Research area · week to 3 Oct 2026

Cardiac Fibrosis and Remodeling

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Metabolic Perturbation Exacerbates Sinoatrial Node Dysfunction in Heart Failure
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.06.704519
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Identification of ion homeostasis-related genes as diagnostic biomarkers for pulmonary arterial hypertension via WGCNA and machine learning.
Frontiers in Genetics · 24 Sept 2026 · Journal Article
S1PR1, CA2, and ABCG2 are identified as key ion homeostasis-related genes with strong diagnostic potential for pulmonary arterial hypertension, with S1PR1 showing protective effects.
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https://jclub.com.au/a/42787432
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Machine Learning identification in patients with aortic valve stenosis of a myocardial miRNA signature predictive of reverse cardiac remodelling after valve replacement
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363736
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Pharmacological and Transcriptomic Exploration of β2-Adrenergic Receptor-Gα15 Signaling in THP-1-Derived Macrophages
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.09.704723
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Differential histone tail citrullination by protein arginine deiminases observed via NMR spectroscopy
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.01.722238
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Three-dimensional Virtual Adult Cardiomyocyte Transcriptomics
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.14.718375
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Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration.
eLife · 8 Sept 2026 · Journal Article
Primordial cardiomyocytes are essential for heart development but not necessary for regeneration in zebrafish, with only 15% capable of regeneration after injury.
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https://jclub.com.au/a/42709570
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Immune Aging is an Independent Risk Factor for Cardiovascular Disease
bioRxiv · 6 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.18.725733
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Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial.
Nature Medicine · 1 Sept 2026 · Randomized Controlled Trial
Mitiperstat, an MPO inhibitor, did not improve symptoms or exercise capacity in 711 patients with heart failure and preserved or mildly reduced ejection fraction over 48 weeks.
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Sulf1 regulates inflammation via modulation of TGF-β dependent epicardial activation.
EMBO Reports · 27 Aug 2026 · Journal Article
Sulf1 modulates TGF-β signaling to regulate epicardial activation and inflammation, affecting heart regeneration in zebrafish.
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https://jclub.com.au/a/42661063
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Systems analysis reveals neuregulin-1 control of cardiomyocyte size and shape mediated by distinct PI3K and p38 pathways
bioRxiv · 25 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.01.679873
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Analytical resolution governs cross-laboratory and cross-species concordance in murine cardiometabolic HFpEF transcriptomics
bioRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.721824
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Freely available genomic datasets for atrial fibrillation research: current resources and analytical pipeline.
Frontiers in Genetics · 24 Aug 2026 · Systematic Review
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https://jclub.com.au/a/42703458
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Integrated analysis reveals neuro-immune pathway in the central nervous system that supports SGLT2is protective effects in treatment of cardiac remodeling
bioRxiv · 20 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.02.674829
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Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type.
Nature Communications · 20 Aug 2026 · Journal Article
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https://jclub.com.au/a/42754619
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NLRP3 inflammasome pathway activation is associated with cardiac remodeling, gut microbiota dysbiosis, and dietary protein restriction in a rat heart failure model: an integrative exploratory analysis.
Frontiers in Genetics · 18 Aug 2026 · Journal Article
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https://jclub.com.au/a/42677289
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Histone lysine demethylase inhibition is a disease-modifying therapy for hypertrophic cardiomyopathy
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.07.743611
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Integrated computational and in vivo evidence prioritizes MYH6 as a candidate node in PFOS-associated HCM-like cardiac remodeling.
Environmental pollution · 14 Aug 2026 · Journal Article
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https://jclub.com.au/a/42600829
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Multi-ancestry genetic architecture of heart failure subtypes.
Nature Communications · 13 Aug 2026 · Meta-Analysis
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https://jclub.com.au/a/42722677
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