L-selectin shedding regulates post-infarction neutrophilia without altering myocardial injury or ventricular remodelling.

Non-cleavable L-selectin in mice markedly attenuates post–permanent coronary ligation neutrophilia, yet leaves myocardial neutrophil representation, infarct size, and ventricular remodelling unchanged.

• Why it matters: MI-linked systemic neutrophilia is associated with injury, but it is unclear whether its magnitude directly shapes cardiac damage or later remodeling.
• What they did: Mice expressing a non-cleavable L-selectin mutant (L(E)) were compared with wild-type after permanent coronary ligation, with CXCL2/CXCR2 assessed and recombinant CXCL2 given intravenously.
• The result: L(E) mice showed reduced circulating CXCL2 and decreased CXCR2 on bone marrow neutrophils, and CXCL2 failed to restore circulating neutrophils; despite this, troponin I, MRI infarct size, and ventricular structure/function through days 1, 14, and 28 were comparable.

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