BACH1 acts as a pioneer repressor, priming chromatin and regulating macrophage plasticity with 3D architecture constraints, crucial for tissue adaptation and inflammation responses.
- Open access
- 3 cites
Genomics and Chromatin Dynamics
Moving in EMBO Journal, Immunity, Nature, Nature Genetics.
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A comprehensive resource of over 92 million human enhancer-gene interactions across 369 tissues advances understanding of gene regulation and disease genetics.
- Open access
- 4 cites
Cumulative transcription factor binding and p300 activity determine enhancer activation frequency in eukaryotic cells.
- 3 cites
Depleting WAPL and CTCF in mouse ESC promotes 2CLC reprogramming through chromatin organization changes, dependent on the DPPA2/DUX pathway, with a 2.5-fold increase observed.
- Open access
- 2 cites
Latest in Genomics and Chromatin Dynamics
Newest first · last 60 days
Blood cell composition accounts for up to 53% of variation in DNA methylation age, with distinct influences on epigenetic clock measures and biological processes.
- Open access
Dense optical genome mapping achieves chromosome-scale assembly of yeast genomes, revealing structural variations and repetitive regions up to 500 kbp in size.
- Open access
Cohesin's dual functions in genome maintenance include sister chromatid cohesion and chromatin loop extrusion, crucial for DNA repair and genome stability.
SAGA and ATAC co-activator complexes use distinct strategies to regulate gene transcription, with implications for cancer therapy.
- Open access
Deep learning genetic perturbation models outperform uninformative baselines when evaluated with calibrated metrics across multiple datasets.
- Open access
Genome-wide mapping reveals conserved cis-regulatory elements in the 3.6 Gbp genome of Parhyale hawaiensis, enabling more efficient identification of functional DNA regions.
- Open access
A human enhancer, eNMU, drives a 10,000-fold increase in NMU gene expression within native chromatin, revealing complex enhancer facilitation mechanisms.
- Open access
- 4 cites
Ageing results from the progressive loss of cellular identity constraints, with 90% of age-related DNA methylation changes occurring at PRC2-bound regions in mammals.
NELF, MLLT1, MLLT3, and INT-PP2A are essential for somatic hypermutation by facilitating stalled PolII and AID targeting in B cells.
- Open access
- 1 cites
Pioneer transcription factor ETS1 primes histone activation and drives 3D genome reorganization during osteoblast differentiation, with B-to-A chromatin shifts pre-marked in pre-osteoblasts.
- Open access
DOT1L regulates ncPRC1 complexes and H2AK119ub1 to sustain germinal center B cell identity in diffuse large B cell lymphoma, with 20 key gene targets identified.
ChromBPNet accurately predicts chromatin accessibility and regulatory variants at base resolution, outperforming larger models with a lightweight design across diverse assays and contexts.
- Open access
- 135 cites
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