Nature Genetics
Nature Portfolio · Genomics & Bioinformatics · ISSN 1061-4036, 1546-1718
- Impact (2-yr)
- 18.5
- h-index
- 795
- Open access
- 40%
- Works
- 11.9K
- Papers this month
- 34
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Moved this week
Integrative multi-omics analyses outperform single modalities but face reproducibility and validity challenges in clinical implementation.
- 3 cites
Nanoparticle-enriched mass spectrometry reveals over 1,200 novel plasma protein genetic associations in British South Asians, advancing understanding of disease mechanisms.
- 3 cites
Cumulative transcription factor binding and p300 activity determine enhancer activation frequency in eukaryotic cells.
- 3 cites
A disease-associated microglial subtype with elevated GPNMB expands with Alzheimer's pathology and depends on TREM2 for neuroprotection.
- Open access
- 20 cites
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Reactivating the silenced embryonic ζ-globin gene restores therapeutic hemoglobin levels in severe α-thalassemia models, including lethal forms like Hb Bart's hydrops fetalis.
- Open access
Lineage transformation to squamous identity enables KRAS inhibitor resistance in mouse lung adenocarcinoma models, independent of KRAS/MAPK pathway reactivation.
ArchMap enables accessible, no-code reference-based analysis of single-cell datasets, democratizing the use of comprehensive atlases for researchers worldwide.
- Open access
Single-cell APA profiling in 2 million human brain cells reveals cell-type-specific genetic regulation linked to neurodegenerative diseases, including Alzheimer’s and Parkinson’s.
- Open access
Evolutionary increases in CCNB1IP1 expression drove cortical expansion and folding in primates, with knock-in experiments inducing cortical folding in mice.
Germline HRD reduces clonal hematopoiesis expansion during platinum and PARP inhibitor therapy, potentially lowering therapy-related myeloid neoplasm risk.
OLR1(+) scar-associated macrophages are linked to liver fibrosis and represent a promising therapeutic target in chronic liver disease, with high OLR1 expression correlating with worse outcomes.
624 common genetic variants influence childhood adiposity, with one-third showing no association with adult BMI, highlighting childhood-specific genetic effects.
Euchromatin forms condensed domains with small, accessible regions that protrude, challenging the traditional view of it as uniformly open.
Single-cell chromatin accessibility analysis reveals that Crohn's disease heritability is mainly enriched in T cells and neutrophils, with 30 noncoding variants located within regulatory elements.
Single-cell multimodal atlas uncovers cellular and regulatory mechanisms driving human facial diversity from embryonic weeks 6-11, highlighting 56 cell states and key enhancers.
KDM2B is a critical dependency in high-risk medulloblastoma subgroups, with its inhibition suppressing tumor growth by altering chromatin states.
Genetic factor analysis reveals 15 pleiotropic components underlying 22 risk factors for coronary artery disease and type 2 diabetes.
Gb3 encodes a unique kinase-pseudokinase fusion protein that confers greenbug resistance in wheat, with transgenic expression enhancing defense against multiple biotypes.
- Open access
Single-nucleus analysis reveals cell-type-specific genetic regulation of 14,258 genes in the human prefrontal cortex, uncovering novel disease-related targets.
- Open access
- 2 cites
Genetic variation influences in vivo protein-protein interactions in yeast, with 12,000 SNPs revealing 61 reporter PPIs and numerous piQTLs.
- Open access
- 1 cites
Computational structural genomics enables atomic-resolution interpretation of human genetic variants, revealing their mechanisms of dysfunction with high precision.
Crop legacy traits influence soil conditions and can be targeted to improve sustainability, with heritable variation present in key crop species.
Interferon-α reshapes human blood development by inducing distinct HSC states, with 50% of mutated stem cells resisting inflammatory myeloid differentiation.
A pan-genome analysis of 14 peanut genomes reveals structural variations and enables the development of high-yield dwarf lines, advancing peanut breeding.
Multiancestry polygenic risk scores (PRSs) trained on diverse datasets improve prediction accuracy, especially in under-represented populations, with gains varying by trait and ancestry.
- Open access
- 1 cites
APOE-stratified GWAS reveal novel genetic signals for Alzheimer's disease, with DDHD1 showing protective effects specifically in APOE ε4 carriers.
- Open access
Updated guidelines for returning secondary genomic findings in observational cohort studies emphasize ethical, equitable, and scalable practices across diverse result types.
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- bioRxiv5569
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- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4