Euchromatin forms condensed domains with short active regions on the surface.

Euchromatin forms condensed domains with small, accessible regions that protrude, challenging the traditional view of it as uniformly open.

• Why it matters: Understanding the 3D organization of enhancers and promoters at nucleosome resolution is crucial for deciphering transcriptional regulation, yet remains poorly characterized.
• What they did: A simulation framework utilizing micro-C contact maps was developed to infer conformational ensembles of megabase regions at nucleosome resolution, revealing structural details.
• The result: The findings show euchromatin consists of condensed domains with protruding, accessible regions, enabling efficient regulatory element interaction and protein binding.