Research area · week to 3 Oct 2026

Dementia and Cognitive Impairment Research

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Nearly Half of Dementia Cases May Be Preventable-Here's What the Research Says So Far.
JAMA · 4 Sept 2026 · News
Nearly 50% of dementia cases could be prevented by addressing modifiable risk factors, highlighting significant potential for reducing Alzheimer’s and other dementias.
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Latest in Dementia and Cognitive Impairment Research

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Real-World Outcomes of a Telephone-Based Virtual Cognitive Rehabilitation Therapy Program: A Retrospective Cohort Analysis
medRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.10.26357703
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Different functional connectivity gradients reflect aging and Alzheimer's disease.
Nature Neuroscience · 1 Oct 2026 · Journal Article
Distinct functional connectivity gradients reveal that aging and Alzheimer's disease alter separate major brain communication pathways, with AD affecting sensory-association and aging impacting representation-executive axes.
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https://jclub.com.au/a/42823476
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EEG Biomarkers for ATN Classification in Early Alzheimer's disease
medRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.26.26356640
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A neurocognitive speech taxonomy for voice biomarkers of Alzheimer's disease
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363671
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A Comparison of Brain Metabolic Connectivity Methods Topology, Cognition, Age, Structure, and Genetics
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.16.752264
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Diagnostic accuracy of remote self-administered digital cognitive assessment by clinical diagnosis and Alzheimer's disease PET imaging biomarkers
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.26362296
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Patterns of modifiable lifestyle, behavioural and health-related risk factors and their associations with incident dementia in UK Biobank
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.26363838
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Speech Timing Measures Are Not Interchangeable Across Elicitation Methods in Senior Living Residents
medRxiv · 25 Sept 2026 · Preprint
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EasyCog: a fast and effective numerical tool for the self-assessment of cognitive functions
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363767
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Study of Ancestry, Health, Environment, and Late-Life Neurodegeneration (SAHEL)
medRxiv · 24 Sept 2026 · Preprint
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Prevalence of dementia among community-dwelling older adults in rural Uganda: findings from DEPEND Uganda (Dementia Epidemiology, unmet need and co-developing solutions in Uganda)
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.18.26363378
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Glycaemic Burden and Cognitive Screen-Positive Status in Younger Indian Adults with Long-Standing Type 2 Diabetes: A Cross-Sectional Study with a MoCA Cutoff Sensitivity Analysis in a Lower-Education Population
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363620
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Ceperognastat in Early Symptomatic Alzheimer Disease: A Randomized Clinical Trial.
JAMA · 22 Sept 2026 · Randomized Controlled Trial
Ceperognastat failed to significantly slow disease progression in early symptomatic Alzheimer disease at 100 weeks, despite reducing brain volume loss.
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Ceperognastat in Early Symptomatic Alzheimer Disease: Research Summary.
JAMA · 22 Sept 2026 · Journal Article
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https://jclub.com.au/a/42441387
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Blood proteomics of menopause map to brain aging and dementia risk.
Nature Medicine · 22 Sept 2026 · Journal Article
Blood proteomics reveal that menopause is linked to accelerated brain aging and increased dementia risk, with 11,925 women showing consistent associations.
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https://jclub.com.au/a/42773212
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Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment.
JAMA · 15 Sept 2026 · Journal Article
Elevated blood-based p-tau217 levels predict up to 38% risk of cognitive impairment over 10 years in unimpaired older adults.
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https://jclub.com.au/a/42449500
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Predicting Risk of Cognitive Impairment With Alzheimer Disease Blood Biomarkers.
JAMA · 15 Sept 2026 · Comment
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https://jclub.com.au/a/42449502
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APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.
Nature Genetics · 14 Sept 2026 · Journal Article
APOE-stratified GWAS reveal novel genetic signals for Alzheimer's disease, with DDHD1 showing protective effects specifically in APOE ε4 carriers.
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https://jclub.com.au/a/42736378
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Spectral normative modeling of brain structure
medRxiv · 12 Sept 2026 · Preprint
Spectral normative modeling creates highly detailed brain charts, revealing three main cortical growth gradients across the lifespan in over 78,000 healthy scans.
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https://jclub.com.au/a/10.1101/2025.01.16.25320639
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Detection and Continuous Monitoring of Memory Dysfunction in Mild Cognitive Impairment and Healthy Aging Through Adaptive Computational Phenotyping
medRxiv · 12 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.03.15.24304345
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Ancestry-specific effects of APOE on Alzheimer Disease Endophenotypes
medRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.23.26349095
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A Two-Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p-Tau217 Gray Zone
medRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.03.26345302
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A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations.
Nature Genetics · 1 Sept 2026 · Journal Article
A multiancestry polygenic risk score for Alzheimer's disease predicts cognitive decline and neuropathological features across diverse populations, with odds ratios up to 1.65.
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https://jclub.com.au/a/42661068
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Spatiotemporal Characterization of Amyloidosis-Associated Microglial States Reveals Sex Difference in Early Plaque Formation
bioRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.05.716600
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Meta-analysis of glucose metabolism across Alzheimer's, Parkinson's and ALS reveals distinct patterns of cortical hypometabolism versus subcortical hypermetabolism with disease-specific spatial signatures
medRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.07.26350339
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Humanized APP is the primary determinant of regional brain volume in humanized APOE knock-in mice: a cross-sectional ex vivo MRI study
bioRxiv · 25 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.04.722764
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Investigating the Usability, Feasibility, and Effect of a Virtual Reality Cognitive Training System on Brain Cancer Patients with Mild Cognitive Impairment: A Quasi-Experimental (Single-Arm) Pilot Study
medRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.18.26353031
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Modifiable Contributors to Socioeconomic Inequality in Brain Aging
medRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.13.26360373
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Quantifying Uncertainty in Alzheimer's Disease Progression Modelling: A Variational Disease Progression Score Framework
medRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.19.26360855
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MRI-derived brain aging trajectories across the Alzheimer's continuum: links to cognition, pathology and lifestyle risk factors
medRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.19.26360525
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