The abstract is read at the publisher; the summary is JClub's.
In multi-ancestry cohorts, Alzheimer’s disease is linked to eight peripheral immune cell proportion shifts, including lower naive B cells and higher neutrophils, with effects varying by ancestry.
- Why it matters: Immune dysregulation is implicated in AD, but peripheral immune alterations and their ancestry-specific patterns are insufficiently characterized for biomarker or therapeutic development.
- What they did: Whole blood RNA-seq from non-Hispanic White, African American, Caribbean Hispanic, and Peruvian participants was deconvolved with CIBERSORTx; case-control linear models adjusted for age, sex, and APOE, with cell-type differential expression via CARseq and pathway enrichment using MSigDB.
- The result: Across groups, shared pathway signals included heme metabolism, interferon, and oxidative phosphorylation, while ancestry-specific emphases differed (e.g., strongest oxidative phosphorylation in AA myeloid populations; TGF-{beta} and apoptosis signatures unique to PERU).
The findingWhy it mattersWhat they didThe result
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