RNA-triggered chromatin shredding using Cas12a2 selectively eliminates tumor cells with mutations in critical cancer genes like TP53 and MYC in mouse models.
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CRISPR and Genetic Engineering
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Prime editors achieve up to 27.3% precise DNA insertions in zebrafish, enabling accurate genome modifications without exogenous DNA.
- Open access
- 3 cites
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CRISPR RNP-mediated genome editing achieves transgene-free modifications in woody plants but faces significant delivery and regeneration challenges, especially in species like bamboo.
- Open access
- 21 cites
De novo RNA-guided transposition systems using TnpB-family proteins achieve high-efficiency DNA insertion with precise control in bacteria.
- Open access
CAR T cells targeting surface U5 snRNP200, an RNA-binding protein absent from normal hematopoietic precursors, effectively treat AML and B-cell ALL with improved safety.
- Open access
Genomic and transcriptomic qualification of patient-derived dopaminergic neuron precursors was successfully achieved across multiple donors for Parkinson's disease therapy.
- Open access
Proteolytic control of CRISPR-Cas systems achieves precise, tunable gene expression with reduced variability, enabling improved gene therapy for dosage-sensitive disorders.
- Open access
- 2 cites
Viral delivery of PRPF31 restores splicing, cellular function, and visual activity in patient-derived retinal cells, even in mature stages, offering a promising therapy for RP11.
- Open access
A rapid sphingomyelin-dependent entry pathway in S. aureus alters intracellular fate, influencing bacterial replication and host cell death within minutes of contact.
- Open access
- 1 cites
Subpopulations of Acinetobacter baumannii exhibit distinct metabolic responses to polymyxins, with PI-positive cells increasing phosphatidylethanolamine and PI-negative cells upregulating arginine metabolism.
- Open access
Genome-wide CRISPR screens identify 15 cancer driver alterations with numerous synthetic lethal interactions, revealing new therapeutic targets.
- Open access
Ancient viral interactions likely shaped the development of modern class 1 CRISPR bacterial immune systems.
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