Epigenetic regulation by KDM4C and SETD2 controls MYC amplification dynamics, promoting extrachromosomal and inherited genomic events in cancer.
Molecular Cell
Elsevier BV · Cell & Molecular Biology · ISSN 1097-2765, 1097-2765
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DDIAS protects single-stranded DNA during mitosis, promoting neurogenesis and cancer cell survival, with 1,000-fold importance in genome integrity.
DDIAS suppresses mitotic single-stranded DNA and promotes chromosome stability in HR-deficient human cells, with a critical role in genome integrity.
Kinetoplastids have lineage-specific mitochondrial innovations, expanding their proteomes with 124 previously unrecognized proteins, including ten kDNA-encoded components.
Kinetoplastid parasites exhibit both conserved and unique mitochondrial assemblies, with structures revealing nine new subunits and specialized adaptations in respiratory complexes.
Elevated cyclin E-CDK2 activity in cancers suppresses immunotherapy responses by phosphorylating BRD4 and reducing interferon-stimulated gene expression.
Cohesin persists through mitosis and is essential for post-mitotic transcriptional reactivation via Cdk9 in human cells.
Linker histone H1.0 loads onto nucleosomes via multiple pathways facilitated by chaperones, with chaperones significantly enhancing nucleosome targeting and loading efficiency.
CaMKII monomers can bind GluN2B, co-condense, and induce synaptic potentiation, revealing a new mechanism for LTP independent of holoenzyme formation.
De novo RNA-guided transposition systems using TnpB-family proteins achieve high-efficiency DNA insertion with precise control in bacteria.
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Cyclin E-CDK2 influences cancer cell transcription and immunotherapy response by phosphorylating BRD4, with overactivation promoting resistance and inhibition enhancing immune therapy efficacy.
A dual-module ECAS complex links transcription elongation and RNA processing, with AQR perturbation impairing gene elongation and leukemia progression in human and mouse cells.
Kaposin RNA reorganizes nuclear speckles to significantly boost KSHV gene expression, with 80% dependence on its repetitive elements.
Endogenous purine nucleotides and thiopurine drugs act as molecular glues to inhibit purine synthesis by linking PPAT to NUDT5.
Ubiquitin chain editing by ZUP1 promotes p97/VCP-dependent removal of RPA from ssDNA, crucial for DNA repair and genome stability.
ZNFX1 forms pleiomorphic polymers that enhance immune signaling by coupling RNA sensing with ubiquitin signaling.
Nicotinamide nucleotide transhydrogenase (NNT) enables glioma cells to sustain growth under hypoxia by linking NADH oxidation to NADPH production, supporting proline synthesis.
Nicotinamide nucleotide transhydrogenase (NNT) links mitochondrial NAD(P)(H) balance to proline synthesis, supporting hypoxic glioma growth with a significant dependence on NNT activity.
Dorsal clusters in vivo amplify gene expression by increasing polymerase loading without altering transcriptional bursting dynamics in Drosophila embryos.
ZC3H18 promotes first intron splicing by interacting with splicing factors, revealing a new role beyond its known function in RNA decay.
ATM prevents pathological repriming at oxidative DNA lesions, and its absence leads to DNA gaps that cause PARPi sensitivity in mammalian cells.
unZipro achieves a 61% success rate in identifying high-activity protein variants from minimal libraries across nine diverse proteins, boosting gene-editing activity up to 28-fold.
Combinatorial deep mutational scanning reveals epistatic superbinders that bind 3- to 5-fold tighter than existing PIN1 WW-domain binders.
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HUWE1-HAPSTR1-USP7 complex amplifies ubiquitin chains on nuclear proteins, regulating stress-responsive degradation with a key role in neurodevelopmental disorders and cancer.
HoT auto-blinking probes achieve real-time, super-resolution chromatin imaging in live cells and tissues with high stability and temporal resolution.
A highly structured 3'-end domain of CONCR lncRNA is essential for DDX11 binding, activating ATPase activity, and ensuring DNA replication and sister chromatid cohesion.
HP1α creates a local transcription barrier that persists during chromatin decondensation, withstanding activation and maintaining nanodomain segregation in mouse heterochromatin.
Oriented binding of ELF2 and YY1 to nucleosomes at human promoters enhances transcriptional activity by making TSSs accessible.
PTI activates alternative splicing of potato NLR Rpi-vnt1.1 mRNA, removing a repressive prodomain and enabling immune response, revealing a new immune regulation layer.
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