Identification and regulation of an ACC1-associated lipogenic metabolon in liver.

ACC1 forms a nutrient-responsive lipogenic metabolon in mouse liver models and primary rat hepatocytes, enriching DNL and TG synthesis enzymes at lipid droplet and mitochondria–LD interfaces.

• Why it matters: Hepatic DNL contributes to triglyceride buildup in metabolic dysfunction-associated steatotic liver disease (MASLD), yet the post-translational organization that boosts lipogenesis is not well defined.
• What they did: The study used immunofluorescence and electron microscopy to show ACC1 interactions with multiple DNL and TG synthesis enzymes under anabolic conditions, and compared interaction patterns in steatotic livers.
• The result: In steatotic livers, ACC1-associated lipogenic protein interactions increased, implying enhanced hepatic lipogenesis and suggesting that disrupting this metabolon could be a therapeutic strategy for MASLD.

AI summary of the abstract · may contain errors · not medical advice · read the paper.