Tuberculosis Research and Epidemiology
Moving in bioRxiv, medRxiv, Nature Microbiology, Journal of bacteriology, Nature Communications, Cell Host & Microbe, eLife, Genome Medicine.
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Latest in Tuberculosis Research and Epidemiology
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Semapimod inhibits L-leucine uptake in Mycobacterium tuberculosis, reducing bacterial load in infected mice despite no in vitro efficacy.
- Open access
Tobramycin increases Mycobacterium abscessus survival by inducing whiB7, promoting persistent infection in cystic fibrosis airway conditions.
- Open access
Migration increased genetic diversity of Mycobacterium tuberculosis in Hamburg but did not significantly change local transmission patterns, which remained lineage-specific.
- Open access
Strong, sustained type I IFN signaling intrinsically impairs IFNγ responses in macrophages, increasing susceptibility to tuberculosis in Mycobacterium tuberculosis infection.
- Open access
Multiple local PfDHFR I164L haplotypes have expanded in Uganda, increasing pyrimethamine resistance from 19.4% to 32.4% between 2016 and 2022.
- Open access
Deletion of rv3400 in Mycobacterium tuberculosis causes a 30-fold increase in β-D-glucose-1-phosphate and impairs trehalose-based growth, highlighting its essential role in metabolism.
- Open access
Cryo-EM structures reveal how the M. tuberculosis DprE1-DprE2 complex interacts with anti-tubercular drugs, providing insights into their mechanisms of inhibition.
Machine learning identifies key chemical features, including nitrogen-containing aromatic scaffolds, that enhance mycobacterial outer membrane permeation, improving antibiotic potential.
- Open access
Genomic surveillance uncovers widespread co-occurrence of drug resistance variants in Plasmodium falciparum across Ethiopia, threatening malaria control efforts.
- Open access
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Moving areas, week to 3 Oct 2026
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