Threat intensity primarily drives innate decision-making in mice, with dominant individuals showing increased vigilance and risk aversion, as revealed by a new computational model.
- Open access
- 1 cites
eLife
eLife Sciences Publications Ltd · General Science & Medicine · ISSN 2050-084X
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Prime editors achieve up to 27.3% precise DNA insertions in zebrafish, enabling accurate genome modifications without exogenous DNA.
- Open access
- 3 cites
Viral attachment to Escherichia coli significantly decreases under energy-limited conditions, with weaker-binding phages being most affected, impacting infection success.
- Open access
Circadian and sleep disruptions in Drosophila melanogaster cause significant metabolic dysregulation, with mutant and constant darkness conditions showing impaired redox homeostasis.
- Open access
- 1 cites
Single-cell transcriptomics of mouse anterior segment development reveals 130,000 cells and key pathways driving trabecular meshwork and Schlemm's canal formation.
- Open access
The T6SS on an ICE enables Bacteroides to maintain strain stability in a wild mammalian gut microbiome, with 20% of related species harboring this system.
- Open access
- 1 cites
Learning significantly enhances behavioral individuality in genetically identical Drosophila, with persistent effects observed across 90 genetic backgrounds.
- Open access
- 1 cites
Distinct pediatric intestinal cell states at diagnosis predict Crohn's disease severity and response to anti-TNF therapy, with treatment shifting toward a more refractory adult-like profile.
- Open access
- 5 cites
Sibling-derived microglia comprise up to 52% of microglial cells in marmoset brains, highlighting extensive hematopoietic chimerism within neural tissue.
- Open access
- 6 cites
Latest in eLife
Newest first · last 60 days
The T6SS on an ICE enables Bacteroides to maintain strain stability in a wild mammalian gut microbiome, with 20% of related species harboring this system.
- Open access
- 1 cites
Mapping contrast sensitivity across the entire visual field with fMRI reveals reliable patterns even with fixation variability in seven participants.
- Open access
Gp41-directed antibodies neutralize HIV-1 by allosterically stabilizing or opening Env conformations, revealing two distinct modes of neutralization with long-range effects.
- Open access
Gut-specific knock-down of enteroendocrine hormones AstC and Tk reduces fat storage exclusively in female Drosophila, highlighting sex-biased hormonal regulation.
- Open access
Negative affect amplifies the bias toward tastiness over healthiness in food choices, especially in individuals with bulimia nervosa, increasing binge episode risk.
- Open access
Genome-wide mapping reveals conserved cis-regulatory elements in the 3.6 Gbp genome of Parhyale hawaiensis, enabling more efficient identification of functional DNA regions.
- Open access
Bidirectional actomyosin redistribution drives epithelial invagination, with 2 distinct phases involving apical constriction and lateral contractility in ascidian siphon tube development.
- Open access
Reorganization of anterior cingulate cortex-CA1 communication after learning selectively suppresses superficial CA1 neurons, aiding memory consolidation.
- Open access
A biophysically detailed mean-field model of neuronal populations reveals how ion-exchange mechanisms influence brain activity, capturing diverse patterns and modulating neural dynamics.
- Open access
- 1 cites
Learning significantly enhances behavioral individuality in genetically identical Drosophila, with persistent effects observed across 90 genetic backgrounds.
- Open access
- 1 cites
Intracellular zinc directly inhibits the sperm-specific Slo3 potassium channel by up to micromolar concentrations, with slow dissociation dynamics, affecting sperm capacitation.
- Open access
Gβ3γ3 acts as a critical positive allosteric modulator, reorienting PLCβ3 to enhance activation and PI(4,5)P2 hydrolysis at the plasma membrane.
- Open access
Single-cell spatial mapping of 26 gastruloids reveals consistent cell type organization and spatially dependent gene expression patterns, with notable meso-scale variability.
Depression dampens mood fluctuations through RPE hyposensitivity, while anxiety heightens them via RPE hypersensitivity, revealing distinct computational signatures in mood disorders.
An early-career researcher’s international journey highlights the hidden challenges faced during cross-continental academic mobility, with 3 major stages from West Africa to Western Canada.
A YOLOv8-based system achieves over 82.9% precision and 91.5% recall in real-time identification of freely moving common marmosets, matching human accuracy.
- Open access
PKD2L1 channels in cerebrospinal fluid-contacting neurons act as dual-mode pH sensors, with high sensitivity around physiological pH levels.
- Open access
Hyperphosphorylated tau disrupts microtubule envelopes and impairs lysosome transport, contributing to neurodegeneration in tauopathies like Alzheimer's disease.
- Open access
Cryo-EM structures reveal a bifunctional TDM enzyme with a novel channeling pathway that guides formaldehyde to a remote tetrahydrofolate site, enhancing metabolic efficiency.
- Open access
Lifelong suppression of Or42a odor responses occurs after a critical period in Drosophila, driven by glial pruning that is highly selective for this sensory pathway.
- Open access
Retinal curl serves as a key functional signal for heading estimation, causing systematic perceptual biases that depend on gaze direction.
- Open access
A modular framework improves spike sorting accuracy and efficiency, outperforming Kilosort4 on dense recordings and enabling detailed assessment of individual algorithm steps.
- Open access
Cooperative action of two conserved Glu/Asp residues is essential for early ATP hydrolysis in GHKL ATPases, with mutations impairing activity in human disease variants.
- Open access
Circadian and sleep disruptions in Drosophila melanogaster cause significant metabolic dysregulation, with mutant and constant darkness conditions showing impaired redox homeostasis.
- Open access
- 1 cites
Retinal waves, apoptosis, and angiogenesis are tightly synchronized during postnatal mouse retinal development, with apoptotic cells triggering neural activity and vascular growth.
- Open access
Closed-loop neurofeedback and movement systems enable mice to modulate cortical activity and improve movement performance within days, with significant statistical support.
- Open access
Cichlid fishes exhibit over a threefold acceleration in tooth replacement after plucking, revealing dynamic cellular and molecular changes during regeneration.
- Open access
Disrupting activity in a specific subset of dopaminergic neurons during memory consolidation impairs long-term memory by causing sleep fragmentation in Drosophila melanogaster.
- Open access
Machine learning identified over 130 repellent odorants for honey bees, with seven confirmed to strongly repel foraging bees in field tests.
- Open access
Region-specific mechanosensory neurons regulated by Hox genes are essential for Drosophila larva self-righting, with anterior inhibition increasing head casting and prolonging recovery times.
- Open access
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- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4