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The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.
eLife · · Journal Article · Open access
Kitto, Huang + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
HIF-1–mediated signaling in Caenorhabditis elegans ADF serotonergic neurons is necessary and sufficient to extend lifespan via a neural circuit.
- Why it matters: Hypoxia can improve health and lifespan, but tissue-specific negative effects limit translation to mammals, so the longevity-promoting components must be identified.
- What they did: The authors mapped a cell-nonautonomous pathway downstream of hypoxic-response activation, testing roles for HIF-1 in ADF neurons and serotonin receptor SER-7 in RIS interneurons, plus tyramine, GABA, and the neuropeptide NLP-17.
- The result: Oxygen- and carbon-dioxide-sensing neurons act downstream of HIF-1, defining a circuit that links hypoxic-response induction to aging modulation and suggests mammalian targets.
The findingWhy it mattersWhat they didThe result
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- Open access
- 1 cites