Research area · week to 3 Oct 2026

Genetics, Aging, and Longevity in Model Organisms

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Multimodal clocks of human aging.
Cell · 9 July 2026 · Journal Article
Multimodal aging clocks accurately quantify human biological age and reveal coagulation factors as key drivers of multi-organ senescence.
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A protein language model links the E. coli pangenome functional landscape geometry to host proteostasis
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.15.699719
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Condensate-driven triglyceride reduction links α-synuclein to mitochondrial dysfunction.
EMBO Reports · 29 Sept 2026 · Journal Article
α-Synuclein reduces triglyceride levels and disrupts lipid droplet and mitochondrial structure, linking lipid metabolism to neurodegenerative toxicity in C. elegans.
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https://jclub.com.au/a/42811169
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Dietary Restriction Impacts Peripheral Diurnal Rhythms Important for Longevity in Drosophila
bioRxiv · 28 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2023.01.04.522718
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Lifespan-extending downregulation of insulin signalling reduces germline mutation load
bioRxiv · 27 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.05.692572
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Innate immune stress pathway activation underlies heterochromatin dysfunction pathology
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753861
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Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753071
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NLP-12/Cholecystokinin signaling stabilizes sensory dendritic structure and protects neuronal healthspan in Caenorhabditis elegans
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.05.709874
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DNA methylation variability provides a complementary epigenetic signature of aging heterogeneity: Findings from the Canadian Longitudinal Study on Aging and the Baltimore Longitudinal Study of Aging
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.25.671156
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Translation of a small upstream open reading frame functions as a rheostat for the regulation of lin-41 by the Let-7 microRNA in Caenorhabditis elegans
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.750518
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Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila.
Nature · 23 Sept 2026 · Journal Article
Loss of Lsp2 reduces TOP mRNA translation via 4E-BP, extending Drosophila lifespan independently of rapamycin, highlighting a new longevity pathway.
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https://jclub.com.au/a/42778591
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Lsp2 links early-life diet to adult translation and lifespan in Drosophila.
Nature · 23 Sept 2026 · Journal Article
Restricting larval protein intake reduces Lsp2 levels, decreases ribosomal proteins, and extends adult lifespan in Drosophila by up to a significant margin.
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Single-cell analyses reveal tissue-specific contextualization 1 of HIF-1 activity
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.07.02.601765
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Sensory and developmental phenotyping of C. elegans parses autism associated genes into behavioural classifications
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.27.714775
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A miR-10a-5p-γCaMKII axis links periphery-to-brain signaling to cognitive vulnerability during female midlife.
Neuron · 18 Sept 2026 · Journal Article
A miR-10a-5p-γCaMKII axis mediates peripheral signals that increase brain vulnerability during female midlife, with miR-10a-5p levels rising significantly in this period.
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https://jclub.com.au/a/42759510
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Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans.
EMBO Journal · 18 Sept 2026 · Journal Article
Transient changes in H3K27me3 in C. elegans persist for multiple generations, affecting fertility and involving specific histone modifications.
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https://jclub.com.au/a/42760351
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A generator-matrix model quantifies the limited contribution of measured biomarkers to human mortality acceleration
medRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.05.26356402
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An open benchmark and language models for AI in aging biology.
Cell · 17 Sept 2026 · Journal Article
Fine-tuned Longevity-LLMs with 0.6B-9B parameters outperform larger models on aging biology tasks in the LongevityBench benchmark.
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https://jclub.com.au/a/42753698
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Anticipatory metabolic regulation drives the distinct and improved metabolic state of caloric restriction compared to Fasting-Refeeding cycles.
Cell Reports · 17 Sept 2026 · Journal Article
Caloric restriction enhances circadian metabolic regulation and improves glucose and fatty acid metabolism compared to fasting-refeeding cycles, with a significant impact on metabolic health.
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https://jclub.com.au/a/42752091
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Epigenetic Clocks Uncover the Natural History of Ageing in Wild Mice
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.09.648041
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Conservative evolution of genetic and genomic features in Caenorhabditis becei, an experimentally tractable gonochoristic worm
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.09.653148
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MEF-2 repression of GEM-4/Copine expression decreases muscle excitability by increasing gap junction coupling
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.717484
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Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
bioRxiv · 12 Sept 2026 · Preprint
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- 5 cites
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https://jclub.com.au/a/10.1101/2024.07.25.605098
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An automated genetic screen identifies modulators of stress-induced sleep in Caenorhabditis elegans
bioRxiv · 12 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.16.725661
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The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.04.652087
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Mean fitness is maximized in small populations under stabilizing selection on highly polygenic traits
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.17.688329
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Genetic Architecture of Reproduction and Longevity in Historical Dutch Cohorts
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.02.729506
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Network subtypes of cortical similarity reveal molecular correlates of normative and compensatory ageing associated with longevity-gene expression
medRxiv · 7 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.19.25337876
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A dynamical circuit model for C. elegans chemotaxis with emergent sharp turns
bioRxiv · 7 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.09.743732
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Drosophila pseudoobscura third chromosome inversion arrangements have temperature-dependent and sex-specific effects on life history traits
bioRxiv · 4 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.06.716560
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Synaptic adhesion molecule signaling is activated and organized by tyrosine phosphorylation-induced biomolecular condensate formation
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.25.747070
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