AI model predicts spatial gene expression from histopathology slides in breast cancer, identifying subgroups with distinct survival outcomes and improving treatment predictions.
- Open access
- 17 cites
Cell
Cell Press · Cell & Molecular Biology · ISSN 0092-8674, 1097-4172
- Impact (2-yr)
- 41.3
- h-index
- 1.2K
- Open access
- 66%
- Works
- 27K
- Papers this month
- 83
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Multimodal aging clocks accurately quantify human biological age and reveal coagulation factors as key drivers of multi-organ senescence.
- 12 cites
CD8+ T cell immunity enhances tumor cell susceptibility to cuproptosis, improving the effectiveness of inducers in overcoming immunotherapy resistance in preclinical models.
- Open access
- 11 cites
MBS1 protein condensates in chloroplasts provide high-light tolerance by acting as a sunscreening mechanism, reducing photodamage in rice under stress conditions.
- 7 cites
Arc is essential for packaging tau into extracellular vesicles, significantly facilitating intercellular tau transmission in neuronal systems.
- Open access
- 13 cites
A telomere-to-telomere human genome benchmark achieves 99.4% accuracy, adding 701.4 Mb of previously missing autosomal and sex chromosome sequences.
- 35 cites
State predicts cellular responses to perturbations across diverse contexts with over 30% improved accuracy on large datasets.
- 87 cites
Comparative analysis reveals 8,619 mitochondrial proteins across eight species, uncovering conserved families and potential drug targets in eukaryotic pathogens.
- 7 cites
Gut metabolites have opposing effects on CAR-T cell therapy outcomes, with valeric acid improving and indole metabolites impairing treatment efficacy.
CRISPR screens reveal Dusp5 and Zfp219 as key regulators of age-related T cell dysfunction, with Zfp219 ablation improving tumor clearance in aged mice.
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A high-confidence plant mitochondrial proteome of 1,462 proteins was identified, expanding to 1,609 with validation, revealing plant-specific mitochondrial protein families.
Endogenous dynorphin release in the dorsal striatum is essential for goal-directed behavior, with a critical role identified in modulating neural activity at rapid timescales.
Comparative analysis reveals 8,619 mitochondrial proteins across eight species, uncovering conserved families and potential drug targets in eukaryotic pathogens.
- 7 cites
GTP binding to LRRK2's ROC domain triggers activation, while GDP binding enforces autoinhibition, revealing distinct structural mechanisms for PD-linked mutations G2019S and R1441C/G/H.
A geothermal amoeba, Incendiamoeba cascadensis, divides at 63°C and remains motile up to 64°C, setting a new upper temperature limit for eukaryotic life.
Oligodendrocytes actively support CNS function and contribute to disease, with their heterogeneity influencing roles across development, aging, and pathology.
Engineered virus-like particles enable real-time, live-cell transcriptomic profiling without cell lysis, capturing dynamic gene expression over multiple time points.
Acanthamoeba ATP synthase structure shows a direct protein tether linking the TCA cycle to OXPHOS, revealing a unique metabolic adaptation.
DDIAS protects single-stranded DNA during mitosis and is essential for vertebrate brain development, especially in neural progenitor cells.
Trichoderma swollenin activates AtABCB5-dependent auxin efflux, boosting plant development by promoting lateral root growth and cell responses.
ULTRA achieves rapid, high-resolution 3D histology of glioma tissue within 30 minutes, enabling intraoperative mapping of tumor infiltration at single-cell resolution.
ANKRD11 condensates suppress hypertranscribed genes, preventing developmental disorder-related gene overactivation, with loss causing embryonic lethality in mice.
A human enhancer, eNMU, drives a 10,000-fold increase in NMU gene expression within native chromatin, revealing complex enhancer facilitation mechanisms.
- Open access
- 4 cites
Acanthamoeba mitochondria adapt dynamically to oxygen levels, with 1,122 proteins including 381 unique to this organism, revealing complex bioenergetic regulation.
Mutualistic interactions between Arabidopsis and Acinetobacter bacteria enhance phosphorus nutrition under deficiency, with bacteria mobilizing inaccessible P in soil.
TgPRO, a novel regulator in Toxoplasma gondii, controls metabolic gene expression and redox adaptation, with its loss increasing reactive oxygen species at high parasite density.
Gasdermin E-mediated pyroptosis drives lethal hepatic lipid accumulation in WELV-infected hosts, with GSDME knockout providing complete protection.
Single-cell atlas reveals 109 human and 22 mouse striatal cell types and subregion vulnerabilities, highlighting species differences and disease implications.
Salicylic acid modulates plant immunity by differentially phosphorylating NPR1 through central metabolic regulators SnRK1 and TOR, with 2 key phosphorylation sites identified.
Spatial analysis reveals a cachexia-promoting microenvironment in pancreatic cancer involving SEMA4A+ tumor cells, AQP9+ macrophages, and LOXL2+ fibroblasts, which correlates with cachexia severity.
Microbiome signatures associated with five cancer types reveal potential contributors to cancer development and treatment responses in a large real-world cohort.
Enrichment of indole-producing Escherichia coli worsens stroke outcomes via AHR activation in intestinal dendritic cells, with AHR deletion improving prognosis in mice.
Non-invasive, precise gene editing in vivo achieved using a compact, photoswitchable Cas12f activated by focused ultrasound in mice.
Gut metabolites have opposing effects on CAR-T cell therapy outcomes, with valeric acid improving and indole metabolites impairing treatment efficacy.
Cargo molecules with tandem sorting motifs directly nucleate AP-1 lattice formation by bridging complexes, enhancing coat assembly and cargo trafficking in cells.
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Journals this month
- bioRxiv5569
- medRxiv1738
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4