Conserved striatal mechanisms underlying ASD.

Cross-species analysis in autism spectrum disorder links altered striatal neurons and astrocytes to ASD-related changes in social and stereotypic behaviors.

• Why it matters: ASD is associated with disrupted striatal circuitry, but the specific cellular contributors to striatal dysfunction remain unclear.
• What they did: Yuan et al. used an innovative cross-species approach to examine striatal neuron and astrocyte alterations relevant to ASD.
• The result: The identified changes in specific striatal neurons and astrocytes provide new avenues to probe cellular and molecular mechanisms of striatal dysfunction in ASD.

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