Duvakitug demonstrated a significant endoscopic response in 48% of patients with Crohn's disease, with the 900 mg dose exceeding placebo response rates in a phase 2b trial.
- 7 cites
Inflammatory Bowel Disease
Moving in The lancet. Gastroenterology & hepatology.
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Duvakitug significantly improved clinical remission rates in patients with moderate to severe ulcerative colitis, with response rates of up to 48% at week 14.
- 7 cites
Latest in Inflammatory Bowel Disease
Newest first · last 60 days
CAR T cell therapy targeting CD19 can induce long-term remission of intestinal inflammation in ulcerative colitis, revealing a new therapeutic avenue for IBD.
- 1 cites
C. albicans-specific Th17 cells are shared across oral and gut mucosa, with significant enrichment in Crohn's disease, linking commensal fungi to intestinal inflammation.
- Open access
A machine learning scoring system using metabolic biomarkers achieves an AUC of 0.910 for IBD diagnosis, surpassing traditional fecal calprotectin tests.
- Open access
TL1A-activated T cells induce a distinct rectal mucosal signature in Crohn's disease patients with perianal fistulising disease, independent of inflammation and anti-TNF therapy.
- Open access
- 6 cites
Family history of colorectal cancer increases CRC incidence similarly in IBD patients and the general population, especially with multiple affected relatives, but the relative impact is weaker in IBD.
- Open access
Distinct pediatric intestinal cell states at diagnosis predict Crohn's disease severity and response to anti-TNF therapy, with treatment shifting toward a more refractory adult-like profile.
- Open access
- 5 cites
Bioengineering Escherichia coli Nissle 1917 with the ttr operon enables effective treatment of colitis by promoting colonization during inflammation, outperforming traditional therapies.
- Open access
Stool from siblings who later develop Crohn's disease increases colitis severity in germ-free mice, highlighting early microbial differences linked to disease risk.
- 1 cites
A joint consensus defines "IBD with IBS-like symptoms" and recommends standardized evaluation and treatment strategies for patients in remission with persistent gastrointestinal symptoms.
- Open access
Endothelial cell-intrinsic NOD2 signaling is essential for T cell recruitment and immune memory formation in the intestine, with NOD2 driving effector and memory T cell accumulation.
- Open access
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