Large language models like GPT-5.2, Gemini 3.1 Pro, and Claude Opus 4.6 outperform specialized clinical AI tools across multiple medical benchmarks, including real-world queries.
- Open access
- 32 cites
Nature Medicine
Nature Portfolio · General Science & Medicine · ISSN 1078-8956, 1546-170X
- Impact (2-yr)
- 32.6
- h-index
- 773
- Open access
- 32%
- Works
- 16.8K
- Papers this month
- 53
Rebuilt
Moved this week
Over 59% of pancreatic cancer patients treated with daraxonrasib develop resistance through RAS pathway alterations, including KRAS amplification and RTK upregulation.
- Open access
- 5 cites
Latest in Nat Med
Newest first · last 60 days
Five-year survival rates with neoadjuvant immune checkpoint inhibitors reach up to 87.5% in melanoma, significantly outperforming targeted therapies and combination regimens.
- Open access
Semaglutide reduces vascular resistance and prevents fibrosis in kidneys, supporting kidney function preservation in type 2 diabetes with chronic kidney disease.
- Open access
Intravenous VCN-01 combined with gemcitabine and nab-paclitaxel improves overall survival in metastatic pancreatic ductal adenocarcinoma, meeting primary efficacy endpoints in the FAS population.
RO7589831, a WRN inhibitor, shows manageable safety and a 74.2% disease control rate in MSI solid tumors at doses of 150 mg and 600 mg BID.
- Open access
- 1 cites
Reproducibility in biomedical research remains inconsistent despite its critical role in ensuring scientific credibility and public trust.
Oral safiglipron significantly reduces HbA1c by up to 1.45% in early type 2 diabetes over 32 weeks, demonstrating strong glycemic control.
Sex differences in cardiovascular biology are underrepresented in research, hindering tailored diagnosis and treatment for women with heart disease.
Evorpacept combined with trastuzumab, ramucirumab, and paclitaxel achieved an ORR of up to 54.8% in HER2-positive gastric cancer but did not meet the predefined statistical threshold.
Mucosal CAR-T cells persist and cause inflammatory remodeling in enterocolitis, with 10 patients showing severe mucosal dysregulation after BCMA CAR-T therapy.
AI-based analysis of over 6 million nuclei reveals specific cell subpopulations linked to diverse Alzheimer's disease phenotypes.
- Open access
- 1 cites
The multi-cancer early detection test demonstrated a positive predictive value of up to 58% and detected primary cancers in 0.60% to 0.41% of participants across three screening rounds in NHS screening.
- Open access
- 1 cites
EAGLE AI model detects early esophageal cancer with 90% sensitivity and 98.5% specificity from chest CT scans across multiple centers, enabling scalable screening.
- Open access
The PATHFINDER 2 study found that a blood-based multi-cancer early detection test achieved a cancer detection rate of 0.54% with high specificity and positive predictive value in adults aged 50 and older.
- Open access
- 2 cites
A HER2-targeted quadruplet regimen achieved a 55% objective response rate in first-line treatment of HER2-positive unresectable biliary tract cancer, showing promising efficacy.
- Open access
Blood proteomics reveal that menopause is linked to accelerated brain aging and increased dementia risk, with 11,925 women showing consistent associations.
- Open access
A consensus-based guideline with over 60 recommendations standardizes personalized bacteriophage therapy, facilitating safe and effective clinical implementation worldwide.
Levetiracetam extends survival in children with diffuse midline glioma by targeting GABAergic synapses, but not in other glioma subtypes.
- Open access
EBV reactivation in peripheral immune cells up to three months before MS relapse predicts disease exacerbation, with elevated viral transcripts and atypical B cell expansion.
- Open access
AAV gene therapy BBM-H901 is safe and reduces bleeding episodes in 11 adolescents with hemophilia B, with FIX activity reaching an average of 41.8 IU/dl at 52 weeks.
Follow Nat Med in the app
Browse JClub
Journals this month
- bioRxiv5569
- medRxiv1738
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4