Resistance exercise to attenuate lean mass loss during tirzepatide therapy for obesity: a randomized controlled trial.

Adding thrice-weekly resistance exercise to tirzepatide in 120 adults with overweight or obesity attenuated total lean soft tissue loss by 1.09 kg over 40 weeks.

• Why it matters: Incretin-mimetic obesity treatment can reduce lean soft tissue mass, potentially impairing skeletal muscle function, so an effective way to preserve lean tissue is needed.
• What they did: In a two-arm randomized controlled trial, participants received tirzepatide and were assigned to resistance exercise training or usual activities for 40 weeks; adherence to exercise was 91%.
• The result: Total fat mass loss was similar between groups, but total lean soft tissue mass loss was smaller with resistance exercise (P < 0.001), including appendicular lean soft tissue mass, while strength declined with tirzepatide and increased with tirzepatide plus resistance exercise.

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