Machine learning reveals conserved spatial ecotypes in tumor microenvironments across cancers, potentially predicting immune checkpoint therapy response.
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Cancer Discovery
American Association for Cancer Research · Oncology · ISSN 2159-8274, 2159-8290
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Sonrotoclax becomes the first BCL-2 inhibitor approved for relapsed or refractory mantle cell lymphoma, showing over 10-fold greater potency than venetoclax.
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Fasting around chemotherapy improves outcomes in advanced ovarian cancer patients, reducing insulin levels and enhancing treatment success.
- In the news
GLP-1 receptor agonists may prevent progression to stage IV in certain obesity-related cancers, with potential to impact treatment strategies.
- In the news
GRAIL's Galleri MCED test did not significantly reduce late-stage cancers in a large NHS-Galleri trial, with only a modest improvement observed in stage IV cases.
- In the news
Next-generation tyrosine kinase inhibitor sunvozertinib shows superior efficacy over chemotherapy as a first-line treatment for EGFR exon 20 insertion non-small cell lung cancer in the phase III WU-KONG28 trial.
- In the news
Ivonescimab combined with chemotherapy improves overall survival in advanced squamous NSCLC, showing a significant benefit over existing immunotherapy-chemotherapy regimens in a Chinese trial.
- In the news
In vivo CAR T-cell therapy KLN-1010 achieved a 100% overall response rate in all 18 multiple myeloma patients in a Phase I trial.
- In the news
Adding apalutamide to androgen deprivation therapy improves 5-year metastasis-free survival to 78.2% in high-risk localized prostate cancer patients.
- In the news
A 14-protein blood test predicts lung cancer risk over 5 years before detection, including in never-smokers outside current screening guidelines.
- In the news
Latest in Cancer Discov
Newest first · last 60 days
Tumor-secreted ADAMTSL4 activates latent TGFβ1, driving multiorgan wasting and fibrosis in cancer cachexia, with levels correlating to disease severity.
LPL-positive endothelial cells promote T-cell homing and liver metastasis regression by enhancing antigen presentation and immune targeting.
- Open access
Senescent-like neutrophils expressing BHLHE40 promote immunosuppressive and angiogenic niches in colorectal cancer liver metastasis, correlating with poor prognosis.
ADAMTSL4 secreted by tumors activates latent TGFβ1, driving tissue wasting in cancer cachexia, highlighting a new therapeutic target.
Neutrophil senescence driven by glucose deprivation promotes tumor growth by suppressing immune responses in colorectal cancer liver metastases.
Genomic instability influences tumor immune responses differently: mutational instability enhances immunogenicity with neoantigens, while chromosomal instability suppresses immunity via innate immune activation.
Ferroptosis is a microenvironmentally regulated process that requires bridging foundational biology with clinical interventions in tumor settings.
CAR T cells targeting surface U5 snRNP200, an RNA-binding protein absent from normal hematopoietic precursors, effectively treat AML and B-cell ALL with improved safety.
- Open access
MutationProjector, a cancer genotype foundation model, accurately predicts therapeutic resistance and sensitivity across multiple cancer types, surpassing existing methods in all tested contexts.
- Open access
Asynchronous evolution of epithelial and stromal components distinguishes pancreatic cancer from precursor lesions, with stromal reprogramming being a key differentiator.
- Open access
A spatial atlas of muscle-invasive bladder cancer uncovers lineage-specific vulnerabilities and immune structures across 22 tumors.
- Open access
Mismatch repair-proficient Colorectal Cancer evades immune attack through intrinsic secretome-driven suppression, despite identical antigen presentation in 25 words.
- Open access
[18F]RCCB6 PET/CT detects ccRCC metastases with 94.2% sensitivity, outperforming [18F]FDG PET/CT and conventional imaging in accuracy and specificity.
Dietary fatty acid types distinctly influence pancreatic tumor development, with monounsaturated fats promoting and polyunsaturated fats suppressing PDAC progression in mice.
Dietary unsaturated fatty acids differentially influence pancreatic cancer progression by modulating ferroptosis sensitivity, with MUFAs promoting and PUFAs inhibiting tumor development.
- Open access
- 1 cites
AI model Oncoformer accurately predicts cancer development, diagnoses tumors, and stages cancer using health records and imaging data across diverse populations.
- In the news
Genomic context and treatment exposure shape glioblastoma recurrence patterns, with TP53 mutations linked to mesenchymal transition and poorer survival in 40 patients.
RAF/MEK glue compounds enable full-dose pan-RAF inhibitor therapy by spatially modulating RAF, achieving potent tumor suppression in RAS-mutant models.
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Journals this month
- bioRxiv5569
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- Environ Res483
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- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4