FDA initiates real-time reporting pilot with two proof-of-concept clinical trials, including AstraZeneca’s TrAVeRse and Amgen’s STREAM-SCLC studies.
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Lung Cancer Research Studies
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γδ T cells infiltrate small cell lung cancer (SCLC) tumors and predict improved responses to immunotherapy, highlighting their potential as therapeutic targets.
- Open access
γδ T cell-engaging BiTEs demonstrate potent activity against small cell lung cancer, overcoming limitations of traditional CD8+ T cell responses.
Combining radiotherapy with immunotherapy can enhance systemic antitumor immunity, but success depends on balancing local control with immune activation, with some approaches showing promise in specific cancers.
- Open access
A rare inherited EGFR mutation has persisted in Southern Appalachia since the 1700s, now affecting populations and increasing lung cancer risk.
Small cell lung cancer exhibits a high 80% rate of brain metastases driven by neurotropic mechanisms and resistance to current therapies.
Tambotatug pelitecan significantly improves survival and response rates in relapsed small-cell lung cancer compared to topotecan, with fewer severe adverse events.
Heterogeneous resistance mechanisms, including EGFR mutations, bypass signaling, and transformation, emerge in EGFR T790M-positive lung adenocarcinoma after 14.2 months of osimertinib treatment.
- Open access
Proteomic analysis of 267 neuroendocrine carcinomas reveals five subtypes with distinct molecular and therapeutic vulnerabilities, including NAD+ dependency in subtype H.
Talquetamab combined with daratumumab and pomalidomide significantly prolongs progression-free survival in relapsed or refractory multiple myeloma, with 24-month estimates over 81%.
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