The abstract is read at the publisher; the summary is JClub's.
LuCaS+ maps NSCLC at single-cell resolution using 2.5 million nuclei from 454 patients, linking tumor subpopulations with high metastatic potential to prognostic value in early-stage lung adenocarcinoma.
- Why it matters: NSCLC mortality is driven by cellular and molecular heterogeneity, but clinically actionable drivers of metastasis and outcome remain hard to resolve across tumor and microenvironment.
- What they did: The study built a multicenter single-cell RNA-seq atlas (Berlin and Cologne discovery: 364 patients; Munich validation: 90) and analyzed tumor and microenvironmental cell profiles to associate cellular programs with metastatic potential and survival.
- The result: Tumor–immune–stromal integration improved survival prediction across all stages and revealed interaction patterns including monocyte- and fibroblast-driven inflammation in lung adenocarcinoma, VEGF-TGFβ-mediated angiogenic feedback loops in lung squamous cell carcinoma, and immune-permissive niches.
The findingWhy it mattersWhat they didThe result
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