Molecular phenotypes and spatial archetypes reveal distinct CAF identities linked to tissue context, advancing precision targeting in cancer therapy.
- Open access
- 11 cites
Cancer Cell
Cell Press · Oncology · ISSN 1535-6108, 1878-3686
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Spatial multi-omics reveals that liver micrometastases in colorectal cancer originate early and exhibit dormancy, with a six-gene signature linked to disease recurrence and therapy resistance.
- Open access
- 4 cites
GABA signaling is linked to resistance to immune checkpoint inhibitors in TLS-positive tumors, with non-responders showing increased GABA-related activity.
- 3 cites
Latest in Cancer Cell
Newest first · last 60 days
Anti-PD-1 sensitivity in mice is more strongly associated with diet-microbiome-metabolite interactions than with obesity-related metabolic dysfunction, challenging BMI as a sole predictor.
A transient MXD4-dependent proliferative pause enables cancer cells to survive early brain colonization, preventing progression to macrometastases in metastasis models.
Brain-seeding cancer cells exploit an MXD4-dependent proliferative pause that can be targeted to prevent metastatic outgrowth.
Patient-derived organoids enable functional evaluation of CAR T cell therapies in solid tumors, capturing tumor complexity and heterogeneity crucial for clinical success.
γδ T cells infiltrate small cell lung cancer (SCLC) tumors and predict improved responses to immunotherapy, highlighting their potential as therapeutic targets.
- Open access
γδ T cell-engaging BiTEs demonstrate potent activity against small cell lung cancer, overcoming limitations of traditional CD8+ T cell responses.
Protein-informed analysis reveals significantly mutated regions in cancer genomes, advancing understanding beyond traditional gene and hotspot approaches.
Inhibiting TET2 reprograms myeloid cells to enhance radiotherapy and suppress metastasis, improving outcomes in lung cancer models.
A chemotherapy-free combination of HRS-4642 and adebrelimab achieved a 43.2% objective response rate in previously treated metastatic KRAS G12D-mutant pancreatic cancer.
Immune checkpoint inhibitors show time-of-day-dependent effects, with earlier treatment linked to better outcomes in pre-clinical and clinical studies.
Removing an immature cord blood NK cell subset improves CAR NK cell function by preventing trogocytosis-driven dysfunction, enhancing tumor targeting.
EGFR-targeting antibody-drug conjugate SYS6010 shows promise in advanced solid tumors, marking a shift from kinase inhibition to antigen-guided therapy.
Targeting multiple overlooked factors, the Heracles Protocol offers a comprehensive approach to make pancreatic ductal adenocarcinoma more treatable.
Tumor-infiltrating plasma cells targeting citrullinated proteins enable effective CAR T-cell therapies in lung cancer.
Spatial organization of IDH-mutant gliomas shifts from anatomy-driven in low-grade tumors to hypoxia-driven in high-grade tumors, revealing two distinct axes of tumor structure.
- Open access
- 1 cites
Spatial RNA and protein profiling of IDH-mutant gliomas reveals hypoxia and necrosis as key organizers of expansive growth and white-matter tracts as invasion guides.
Detection of molecular residual disease via circulating tumor DNA identifies high recurrence risk in resectable solid tumor patients, enabling more efficient clinical trials.
Remodeling of tumor immune microenvironment predicts ICI response, with 40% of tumors shifting states during therapy and transitions correlating with outcomes.
Genomic evolution in colorectal cancer drives metastatic patterns, with RAS activation increasing risk and WNT activation offering protection across sites.
Genomic evolution in over 7,000 colorectal cancers determines metastatic ability and organ targeting, revealing distinct patterns that influence disease spread.
Immune-state remodeling during therapy predicts outcomes better than baseline tumor microenvironment composition across cancers.
Larger biological age gaps are linked to increased risk of early-onset lung, colorectal, and uterine cancers across different birth cohorts.
A 15-gene signature reveals latent tumor-reactive T cells in bone marrow that can be expanded by immunotherapy, predicting patient responses in bone marrow malignancies.
Latent effector T cells in the bone marrow predict immunotherapy response in multiple myeloma and AML with 80% accuracy.
PIKfyve overexpression in neuroendocrine prostate cancer creates a metabolic vulnerability that can be exploited by dual inhibition of PIKfyve and FASN.
Tumor-infiltrating plasma cells produce tumor-specific antibodies that can be harnessed for targeted cancer therapy, with some showing strong binding to citrullinated proteins.
Cholinergic stimulation triggers a self-amplifying nerve-fibroblast circuit that drives colorectal cancer progression, with high NTN1 expression linked to poor outcomes.
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Moving areas, week to 3 Oct 2026
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- CAR-T cell therapy research7
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- Photosynthetic Processes and Mechanisms4
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