Cancer CellJClub
Intrinsic resistance to KRAS inhibition: Interfering with interferon.
Cancer Cell · · Journal Article
Miguel-López, Drosten
Abstract ↗AI summary
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Sustained MYC activity suppresses innate immune signaling and is identified as the principal driver of intrinsic resistance to KRAS inhibition in patient-derived pancreatic ductal adenocarcinoma organoids.
- Why it matters: KRAS inhibition often fails due to intrinsic resistance, but the mechanisms in pancreatic ductal adenocarcinoma organoid models are not well defined.
- What they did: Zhang et al. used multi-omics profiling across a large collection of patient-derived pancreatic ductal adenocarcinoma organoids to map pathways linked to KRAS inhibition resistance.
- The result: The findings implicate innate immune signaling suppression via sustained MYC activity, providing a mechanistic basis for targeting resistance in this organoid context.
The findingWhy it mattersWhat they didThe result
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