Spatial multi-omics reveals that liver micrometastases in colorectal cancer originate early and exhibit dormancy, with a six-gene signature linked to disease recurrence and therapy resistance.
- Open access
- 4 cites
Cancer Genomics and Diagnostics
Moving in Cancer Cell, Cancer Research, The Lancet Oncology.
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Access to cancer genomics and precision oncology remains profoundly unequal worldwide, limiting benefits for millions of patients and hindering research progress.
- 10 cites
Multiomics, computational biology, and ancestry-specific genomics are transforming proactive cancer care with new insights into tumor biology and targeted therapies.
- 1 opens in JClub
Latest in Cancer Genomics and Diagnostics
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Cancers exhibit a four-fold higher mutation burden than normal tissues across five organs, driven by individual baseline mutation rate differences.
Simulation-guided clinical trial design enhances decision-making and accelerates drug development by optimizing complex adaptive strategies.
Access to cancer genomics and precision oncology remains profoundly unequal worldwide, limiting benefits for millions of patients and hindering research progress.
- 10 cites
Multimodal lineage tracing combined with advanced computational methods enables detailed reconstruction of cellular development with high accuracy and resolution.
3D multi-omics tumour atlases reveal complex cellular interactions and evolution, offering new insights into tumor biology and potential clinical applications.
A ReAct agentic AI system achieves 93.4% accuracy in natural language querying and analysis of TCGA clinical data, surpassing rule-based and LLM baselines.
- 1 opens in JClub
- Open access
Lower-GDP countries have significantly reduced uptake of essential cancer medicines, especially those requiring complex genomic diagnostics, with the lowest access observed in low-income regions.
- Open access
DePass achieves superior multi-omics data integration across six modalities and 13 platforms, revealing detailed tissue heterogeneity at near single-cell resolution.
- Open access
- 1 cites
Inhibition of microhomology-mediated end joining reduces ecDNA levels and impairs cancer cell fitness by targeting TA-rich breakage sites.
- Open access
Crumblr enhances detection of cell composition differences by increasing statistical power 2- to 3-fold in single-cell RNA-seq data analysis.
- Open access
- 2 cites
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Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
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- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4