3D multi-omics tumour atlases reveal complex cellular interactions and evolution, offering new insights into tumor biology and potential clinical applications.
Nature Reviews Cancer
Nature Portfolio · Oncology · ISSN 1474-175X, 1474-1768
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Cancer-associated extracellular vesicles and particles cause widespread systemic dysfunction, affecting multiple organs and contributing to disease progression and host mortality.
Activation of gasdermin-induced pyroptosis in cancer cells triggers potent antitumour immune responses with minimal toxicity.
Early-onset colorectal cancer (EOCRC) cases under age 50 are rising globally, with lifestyle and early-life factors contributing to the increasing burden.
Replication stress drives tumor evolution and creates therapeutic vulnerabilities, with over 100 clinical trials exploring ATR, CHK1, and WEE1 inhibitors.
Viral mimicry escape is essential for cancer transformation, enabling malignant cells to bypass immune responses and promote tumor progression.
Population genetics reveals that cancer evolution can be quantitatively understood through models of mutation, selection, and drift, transforming genomic data into evolutionary insights.
Single-cell technologies reveal how genotypes and phenotypes co-evolve in human tissues, uncovering mutant-specific traits and therapeutic vulnerabilities in cancer.
Neutrophils predominantly promote tumor growth and metastasis in cancer, but can also mediate tumor cell killing depending on environmental cues.
Non-invasive imaging of cancer hallmarks enables real-time monitoring and stratification of tumors, with some techniques already impacting clinical treatment decisions.
DDR deficiencies and inhibitors significantly boost cancer immunotherapy responses by generating immunogenic signals that activate immune pathways.
Genomic and epigenomic profiling reveal over 40 molecular subtypes of acute lymphoblastic leukemia, enhancing classification and informing treatment strategies.
Viral exposures beyond oncogenesis can enhance cancer immunity, with endogenous retroviruses and microbiome-associated phages playing protective roles.
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