Boosting CAR T cell efficacy in cancer with metabolic insights from design to diet.

Metabolic and dietary strategies can significantly enhance CAR T cell therapy efficacy, especially in treating solid tumors, by improving T cell persistence and function.

• Why it matters: Current CAR T cell treatments face limitations in achieving long-lasting responses in solid tumors, partly due to metabolic constraints affecting T cell performance and the lack of standardized manufacturing protocols.
• What they did: The review analyzes how CAR design, manufacturing conditions, and host metabolism influence T cell metabolic profiles, emphasizing the potential of diet-based interventions to modulate systemic metabolism.
• The result: Integrating metabolic insights with dietary approaches offers a promising pathway to overcome existing barriers, enabling more durable and effective CAR T cell therapies for challenging cancers.