TCR origin and antigen recognition shape peripheral Treg cell differentiation, with TCRs from Treg cells more effectively inducing tolerance across diverse antigens.
T-cell and B-cell Immunology
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Metabolic reprogramming in lymphocytes, including increased glycolysis and mitochondrial dysfunction, drives T-cell-mediated autoimmunity in diseases like MS, RA, and T1D.
- Open access
MARCH2 and MARCH3 redundantly target FcγRI for K27-linked polyubiquitination and degradation, limiting inflammatory responses and disease severity.
Persistent expansion of alloreactive T cell clones and phenotypic plasticity drive severe graft-versus-host disease in human transplant recipients.
Mismatch repair-proficient Colorectal Cancer evades immune attack through intrinsic secretome-driven suppression, despite identical antigen presentation in 25 words.
- Open access
HnRNPK limits memory B-cell and plasma cell differentiation, maintaining germinal center B-cell output by regulating transcription and metabolism.
Loss of histone readers MLLT1 and MLLT3 eliminates all AID-dependent mutagenic activity, highlighting their essential role in locus-specific antibody diversification.
- 1 cites
NELF, MLLT1, MLLT3, and INT-PP2A are essential for somatic hypermutation by facilitating stalled PolII and AID targeting in B cells.
- Open access
- 1 cites
CytoVI enables comprehensive analysis of antibody-based single-cell data, accurately modeling 350 proteins and revealing disease-related immune cell states.
- Open access
Targeting ZMYND8 enhances IL-2 signaling, promoting effector-like CD8+ T cell responses and improving antiviral and antitumor immunity.
- Open access
Mucosal CAR-T cells persist and cause inflammatory remodeling in enterocolitis, with 10 patients showing severe mucosal dysregulation after BCMA CAR-T therapy.
CD40 activation in B cells enhances anti-tumor immunity by promoting CD8+ T cell infiltration and cytotoxic function in high-mutation tumors.
- Open access
A super enhancer between HLA-DR and -DQ genes regulates their expression through microdomains, with specific regions controlling HLA-DQA1 and HLA-DRB1 levels.
- Open access
DGKα and ζ deficiency in regulatory T cells causes their destabilization and conversion to pathogenic Tfh cells, triggering IgG1-predominant autoimmunity.
- Open access
- 1 cites
γδ T cell-engaging BiTEs demonstrate potent activity against small cell lung cancer, overcoming limitations of traditional CD8+ T cell responses.
PreGame identifies tumour-reactive γδ T-cell receptors with broad reactivity, revealing potential for universal immunotherapy in multiple myeloma and other cancers.
- Open access
Mature NK cell subsets with varying proliferative abilities generate stochastic clonal heterogeneity during early MCMV response, driven by proliferation and cell death dynamics.
- Open access
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