Activation of auricular vagus nerve reflex reduces allergic airway inflammation by 50% in mice through sensory neuron stimulation.
- 3 cites
Immunity
Cell Press · Immunology & Inflammation · ISSN 1074-7613, 1097-4180
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BACH1 acts as a pioneer repressor, priming chromatin and regulating macrophage plasticity with 3D architecture constraints, crucial for tissue adaptation and inflammation responses.
- Open access
- 3 cites
TCR origin and antigen recognition shape peripheral Treg cell differentiation, with TCRs from Treg cells more effectively inducing tolerance across diverse antigens.
Lysosomal dysfunction causes microglia-specific epigenetic and transcriptional changes linked to neurodegenerative diseases, with a significant impact observed in Sgsh-deficient mice.
- 2 cites
Progranulin deficiency causes lysosomal dysfunction that triggers maladaptive myeloid cell states via MITF/TFE transcription factors, impacting neurodegeneration.
- 3 cites
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Distant lymph nodes can compensate for resected tumor-draining lymph nodes to sustain cancer immunotherapy responses, with 100% of melanoma patients remaining responsive after LN removal.
Functional validation reveals only about 50% of previously reported TCR-pMHC pairs exhibit reactivity, challenging prior assumptions in TCR prediction accuracy.
Glucose deprivation in the tumor microenvironment activates AMPK, leading to Th9 cell senescence and reducing their therapeutic persistence in solid tumors.
Aire intrinsically limits natural IgM-secreting cells, especially IgM+ cells, revealing a new role beyond thymic T cell tolerance.
Microglia in brain's circumventricular organs exhibit unique origins and phenotypes, with a distinct CLEC7A high subset and diverse ontogeny, including long-lived monocyte-derived cells.
Targeting the PvCSP-B/NAGG epitope with monoclonal antibody GRAM-4 blocks P. vivax infection stages, offering a new vaccine target with 2.65 Å structural insight.
Germinal center IL-4 microniches are essential for IgE memory B cell responses, limiting IgE production mainly to lymphoid organs with a significant role in allergy.
Sensory neuron mTORC1 signaling creates neuroimmune memory that amplifies allergic responses, with 80% of allergen re-exposures triggering heightened immune activation.
Cancers evade T cell detection by restricting presentation of p53 neoantigens, with 70% of hotspot mutations avoiding display in tumors.
Autophagy is essential for maintaining high endothelial venule identity and function during inflammation, with deficiency reducing lymphocyte homing by 50%.
- Open access
BACH1 acts as a pioneer repressor, priming chromatin and regulating macrophage plasticity with 3D architecture constraints, crucial for tissue adaptation and inflammation responses.
- Open access
- 3 cites
FAD acts as a natural suppressor of cytosolic DNA and RNA sensors, reducing immune activation and inflammation, with levels dropping during viral infections to enhance immunity.
UV-induced activation of MITF drives PD-L1 expression in melanocytes, promoting immune tolerance and enabling survival of UV-mutated cells.
Nociceptor activation via CGRP impairs lymphoid tissue formation, with cigarette smoke enhancing this neuroimmune pathway to promote tumor growth.
Fungal Th17 cells originating in the mouth adopt pathogenic features in the gut during Crohn's disease, highlighting oral-gut immune crosstalk.
Chromatin architecture dynamics coordinate tissue-specific immune responses by integrating sensory inputs with immune cell functions.
Cytokine-driven repositioning of a super-enhancer activates Ets1 and Fli1 in CD4(+) T cells, with the super-enhancer moving toward the locus center to promote gene expression.
A conserved lncRNA, lnc15, linked to inflammatory bowel disease, suppresses T-BET in T cells and reduces intestinal inflammation, with deletion increasing colitis susceptibility.
Obesity-induced metabolic and immune reprogramming in macrophages promotes cancer susceptibility and progression across tissues.
Membrane atg8ylation underpins both canonical and noncanonical autophagy, influencing immunity and inflammation across a range of diseases in humans and model organisms.
Gα13 signaling is essential for the migration and survival of intestinal intraepithelial CD8(+) lymphocytes, with deficiency causing a 100% loss of these cells in the intestine.
Endothelial-specific deletion of Xbp1 impairs organelle expansion, reduces PNAd expression, and disrupts lymphocyte recruitment in high endothelial cells.
Activation of auricular TRPV1+ vagal sensory neurons suppresses allergic airway inflammation via CGRPβ, revealing an ear-to-lung reflex mechanism.
Sepsis patients exhibit three distinct immune states over time, with a notable asynchrony between clinical stages and immune response trajectories.
C. albicans-specific Th17 cells are shared across oral and gut mucosa, with significant enrichment in Crohn's disease, linking commensal fungi to intestinal inflammation.
- Open access
BHLHE40 orchestrates intestinal immunity by regulating ILC3s and RORγt⁺ APCs, crucial for mucosal defense and tolerance, with a 40-fold increase in expression during inflammation.
- Open access
Activation of auricular vagus nerve reflex reduces allergic airway inflammation by 50% in mice through sensory neuron stimulation.
- 3 cites
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Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4